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Intravenous bolus injections of saline and of 50, 100, and 200 mg ranitidine and 300 mg cimetidine were tested. Ranitidine (100 and 200 mg) and cimetidine (300 mg) caused a significant increase in PRL secretion, whereas saline and ranitidine (50 mg) did not. TSH and GH secretion were unaffected by all doses. A dose\u2010response relationship between ranitidine and PRL was established, and a dose of 65 mg ranitidine was found to be the minimal effective PRL\u2010releasing dose. Plasma ranitidine concentration was measured by specific RIA. The results indicate an effect of H<jats:sub>2<\/jats:sub>\u2010receptor antagonists on physiological functions in the control of PRL secretion. Histamine, therefore, may play a role in the regulation of PRL secretion.<\/jats:p>","DOI":"10.1111\/j.1365-2265.1981.tb00705.x","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T13:04:03Z","timestamp":1205759043000},"page":"585-592","source":"Crossref","is-referenced-by-count":21,"title":["COMPARISON BETWEEN DOSE\u2010RESPONSES OF PROLACTIN, THYROID STIMULATING HORMONE AND GROWTH HORMONE TO TWO DIFFERENT HISTAMINE H<sub>2<\/sub>\u2010RECEPTOR ANTAGONISTS IN NORMAL MEN"],"prefix":"10.1111","volume":"15","author":[{"given":"U.","family":"KNIGGE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"WOLLESEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"DEJGARRD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"THUESEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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