{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:50:43Z","timestamp":1767829843082,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,16]],"date-time":"2004-03-16T00:00:00Z","timestamp":1079395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objective<\/jats:sc>\u2002<\/jats:bold> Miscarriage is the commonest complication of human pregnancy. We undertook this study to assess whether inhibin A, pro\u2010\u03b1C inhibin and\/or activin A, products of the corpus luteum and placenta, might be useful in either the prediction or diagnosis of miscarriage.<\/jats:p><jats:p><jats:bold><jats:sc>design<\/jats:sc>\u2002<\/jats:bold> Case\u2013control study.<\/jats:p><jats:p><jats:bold><jats:sc>patients<\/jats:sc>\u2002<\/jats:bold> Ninety\u2010eight asymptomatic women at 6\u201313\u00a0weeks gestation who subsequently had a miscarriage and 198 gestation\u2010matched women with a normal singleton pregnancy.<\/jats:p><jats:p><jats:bold><jats:sc>measurements<\/jats:sc>\u2002<\/jats:bold> Maternal serum levels of inhibin A, pro\u2010\u03b1C inhibin, activin A and human chorionic gonadotrophin (hCG) were measured.<\/jats:p><jats:p><jats:bold><jats:sc>results<\/jats:sc>\u2002<\/jats:bold> Inhibin A, pro\u2010\u03b1C and hCG, expressed as multiples of the normal median (MoM; \u00b195% confidence intervals) in the miscarriage cases were significantly lower than in the viable controls, 0\u00b756 (0\u00b748\u20130\u00b769) MoM <jats:italic>vs.<\/jats:italic> 1\u00b700 (0\u00b798\u20131\u00b713) MoM, 0\u00b755 (0\u00b751\u20130\u00b784) MoM <jats:italic>vs.<\/jats:italic> 1\u00b70 (0\u00b786\u20131\u00b722) MoM and 0\u00b734 (0\u00b723\u20130\u00b736) MoM <jats:italic>vs.<\/jats:italic> 1\u00b700 (0\u00b794\u20131\u00b708) MoM, respectively (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b70001 for all). Of the three analytes, hCG was the most discriminating between cases and controls. Levels of activin A in the miscarriage cases were not significantly different from controls, 0\u00b796 (0\u00b786\u20131\u00b707) <jats:italic>vs.<\/jats:italic> 1\u00b70 (0\u00b795\u20131\u00b708).<\/jats:p><jats:p><jats:bold><jats:sc>conclusions<\/jats:sc>\u2002<\/jats:bold> These data suggest that inhibin A, pro\u2010\u03b1C inhibin and activin A will not be useful in either the prediction or diagnosis of early pregnancy miscarriage.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02005.x","type":"journal-article","created":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T20:29:39Z","timestamp":1103660979000},"page":"484-490","source":"Crossref","is-referenced-by-count":18,"title":["First trimester levels of inhibins and activin A in normal and failing pregnancies"],"prefix":"10.1111","volume":"60","author":[{"given":"Euan M.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Budi","family":"Marjono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Tyzack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341904"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.5.1557"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.12.3530"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1996.tb02722.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.4.1471"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg187"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00512-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.6.1490"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1710057"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02648.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09264-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.12.3072"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55628-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.2.558"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00480-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.985"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.12.5794"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01686.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb00979.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.9.2028"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970150410"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.1.218"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02190.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807283190401"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2004.02005.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2004.02005.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:11:51Z","timestamp":1697231511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2004.02005.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,16]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.1365-2265.2004.02005.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2004.02005.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,16]]}}}