{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:31:14Z","timestamp":1787988674363,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T00:00:00Z","timestamp":1084838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objective\u2002<\/jats:sc><\/jats:bold> The present study was to compare the efficacy of a single daily dose of methimazole (MMI) and propylthiouracil (PTU) in the treatment of Graves\u2019 hyperthyroidism.<\/jats:p><jats:p><jats:bold><jats:sc>background\u2002<\/jats:sc><\/jats:bold> Antithyroid drugs, MMI and PTU, are widely used in the treatment of hyperthyroidism. Previous studies in the treatment of hyperthyroidism with a single daily dose of antithyroid drugs have demonstrated a more favourable result with MMI. However, the efficacy of a single daily dose of PTU was inconsistent. In this study, we examined the therapeutic efficacy of single daily doses of MMI and PTU on the change of thyroid hormones and thyrotropin receptor antibodies (TRAb) levels.<\/jats:p><jats:p><jats:bold><jats:sc>methods\u2002<\/jats:sc><\/jats:bold> Thirty patients with newly diagnosed Graves\u2019 hyperthyroidism were randomly divided into two groups, each receiving a single dose of either 15\u00a0mg MMI or 150\u00a0mg PTU daily for 12\u00a0weeks. The therapeutic efficacy was determined by serum total triiodothyronine (TT3), total thyroxine (TT4), thyrotropin (TSH), free thyroxine (FT4), and TRAb levels at baseline and at the end of 4, 8 and 12\u00a0weeks during the study period.<\/jats:p><jats:p><jats:bold><jats:sc>results\u2002<\/jats:sc><\/jats:bold> There was no significant difference in baseline thyroid function parameters. Serum TT3, TT4 and FT4 levels in the MMI\u2010treated group were significantly lower than those of the PTU\u2010treated group after 4 weeks and through the end of the study. MMI also has superior effect on reducing serum TRAb levels than PTU after 8\u00a0weeks and at the end of the study.<\/jats:p><jats:p><jats:bold><jats:sc>conclusion\u2002<\/jats:sc><\/jats:bold> During the 12\u2010week treatment of Graves\u2019 hyperthyroidism, a single daily dose of 15\u00a0mg MMI was much more effective in the induction of euthyroidism than a single daily dose of 150\u00a0mg PTU. In the doses used in this study, MMI is preferable to PTU when a once\u2010daily regimen of antithyroid drug is considered for the treatment of Graves\u2019 hyperthyroidism.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02032.x","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T11:53:37Z","timestamp":1085399617000},"page":"676-681","source":"Crossref","is-referenced-by-count":39,"title":["Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves\u2019 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