{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:52:50Z","timestamp":1787961170797,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T00:00:00Z","timestamp":1084838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objective\u2002<\/jats:sc><\/jats:bold> To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children.<\/jats:p><jats:p><jats:bold><jats:sc>patients\u2002<\/jats:sc><\/jats:bold> One hundred and two boys, 13\u00b76\u201315\u00b75\u00a0years of age, who were referred because of short stature and delayed puberty.<\/jats:p><jats:p><jats:bold><jats:sc>methods\u2002<\/jats:sc><\/jats:bold> The boys were randomly allocated to one of the following treatment groups: oxandrolone therapy, 5\u00a0mg\/day for 6\u00a0months (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), testosterone depot, 100\u00a0mg monthly for 3\u00a0months (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) or for 6\u00a0months (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), nutritional programme (<jats:italic>n<\/jats:italic>\u00a0=\u00a017), oxandrolone and nutritional programme (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) or passive observation (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). Boys in the nutritional programmes received 12\u00a0mg\/day iron and 6000\u00a0IU\/week of vitamin A. Outcome measurements were of height, weight, pubertal signs, dietary intake, serum vitamin A, iron, GH and IGF\u20101.<\/jats:p><jats:p><jats:bold><jats:sc>results\u2002<\/jats:sc><\/jats:bold> Six months of vitamin A supplementation induced growth acceleration similar to that seen in the oxandrolone\u2010 and testosterone\u2010treated children, and significantly greater than in the observation group (9\u00b73 \u00b1\u00a02\u00b79 <jats:italic>vs.<\/jats:italic> 4\u00b70\u00a0\u00b1\u00a00\u00b79 crn\/yr, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Whereas in the vitamin A\u2010supplemented group, puberty (increase in testicular volume \u2265\u00a012\u00a0ml) was induced within 12\u00a0months. In all testosterone\u2010treated patients, pubic hair was noted within 3\u00a0months and a testicular volume of \u2265\u00a012\u00a0ml was observed 9\u201312\u00a0months after the initiation of therapy. No pubertal signs were noted in the observation group during this time.<\/jats:p><jats:p><jats:bold><jats:sc>conclusions\u2002<\/jats:sc><\/jats:bold> Subnormal vitamin A intake is one of the aetiological factors in delayed pubertal maturation. Supplementation of both vitamin A and iron to normal constitutionally delayed children with subnormal vitamin A intake is as efficacious as hormonal therapy in the induction of growth and puberty.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02034.x","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T11:53:37Z","timestamp":1085399617000},"page":"682-687","source":"Crossref","is-referenced-by-count":13,"title":["Vitamin A and iron supplementation is as efficient as hormonal therapy in constitutionally delayed children"],"prefix":"10.1111","volume":"60","author":[{"given":"Z.","family":"Zadik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sinai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Reifen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.1.108"},{"key":"e_1_2_6_3_1","first-page":"75","article-title":"Nutritional influences on linear growth: a general review","volume":"48","author":"Allen L.H.","year":"1994","journal-title":"European Journal of Clinical Nutrition"},{"key":"e_1_2_6_4_1","volume-title":"Recommended Dietary Allowances","author":"Anonymous.","year":"1989"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/ajcn\/47.3.458","article-title":"Vitamin A analogs as tests for liver vitamin A status in the rat","volume":"47","author":"Burri B.J.","year":"1988","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1997.10.1.51"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1753-4887.1996.tb03866.x","article-title":"Nutritional determinates of puberty","volume":"54","author":"Cameron J.L.","year":"1996","journal-title":"Nutrition Review"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13154.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(93)90069-F"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00325-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.2.136"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00649.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1515\/jpem-2001-s207","article-title":"International Workshop on Management of Puberty for Optimum Auxological Results. 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