{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:55:31Z","timestamp":1792828531525,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T00:00:00Z","timestamp":1086652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p><jats:bold><jats:sc>objective<\/jats:sc>\u2002<\/jats:bold> Double pituitary adenomas are extremely rare. They can be divided into contiguous and clearly separated types. Most contiguous tumours are surgically removed as one tumour and the co\u2010existence of different adenoma types can be confirmed by histological methods. In contrast, detailed preoperative neuroimaging studies can suggest the co\u2010existence of separated multiple adenomas. In patients with multiple adenomas, surgical failure may result when one adenoma is missed during surgery. Among 600 surgical cases we encountered four patients with clearly separated double pituitary adenomas; all were highly suspect on preoperative MRI studies.<\/jats:p><jats:p><jats:bold><jats:sc>patients and results<\/jats:sc>\u2002<\/jats:bold> All four patients manifested acromegalic symptoms; one patient also exhibited hyperprolactinemia and two had familial pituitary adenomas unrelated to multiple endocrine neoplasia type I (MEN\u20101). All underwent transsphenoidal surgery and histology confirmed the diagnosis of GH\u2010producing plus gonadotroph adenoma in two cases and of two GH\u2010producing adenomas each in the other two patients.<\/jats:p><jats:p><jats:bold><jats:sc>conclusion<\/jats:sc>\u2002<\/jats:bold> Although the pathogenesis of our double adenomas remains unknown, genetic abnormalities may be involved because two patients had familial pituitary adenomas unrelated to MEN\u20101. When preoperative MRI is suggestive of double adenomas, careful surgical exploration is necessary to avoid missing the other adenoma because the risk of surgical failure is high, especially in patients with functioning adenomas.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02055.x","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T11:27:09Z","timestamp":1087903629000},"page":"26-30","source":"Crossref","is-referenced-by-count":35,"title":["Preoperative identification of clearly separated double pituitary adenomas"],"prefix":"10.1111","volume":"61","author":[{"given":"Kyongsong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Usui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,8]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"633","article-title":"Unusual MRI finding of multiple adenomas in the pituitary gland: a case report and review of the literature","volume":"17","author":"Cannavo S.","year":"1999","journal-title":"Magnetic Resonance Imaging"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.19.8967"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.36.818"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01286.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01237.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.2.0243"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199211000-00003"},{"key":"e_1_2_5_9_1","first-page":"1885","article-title":"Growth hormone\u2010releasing hormone receptor mRNA in acromegalic pituitary tumors","volume":"150","author":"Lopes M.B.S.","year":"1997","journal-title":"American Journal of Pathology"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020120105651"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011499609096"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.5.0753"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050319"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.6.1974"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009994123582"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343674"},{"key":"e_1_2_5_17_1","first-page":"769","article-title":"Overexpression of the growth\u2010hormone\u2010releasing hormone gene in a acromegaly\u2010associated pituitary tumors","volume":"151","author":"Thapar K.","year":"1997","journal-title":"American Journal of Pathology"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-3-345"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.92.2.0361"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02739885"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.1.239"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2004.02055.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2004.02055.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:54:56Z","timestamp":1697223296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2004.02055.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,8]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1111\/j.1365-2265.2004.02055.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2004.02055.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,8]]}}}