{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:52:37Z","timestamp":1761511957203},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,6,16]],"date-time":"2004-06-16T00:00:00Z","timestamp":1087344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objective\u2002<\/jats:sc><\/jats:bold> To evaluate circulating levels of ghrelin and adiponectin (ApN) in GH\u2010deficient (GHD) adults before and after short\u2010 and long\u2010term recombinant human GH (rhGH) administration.<\/jats:p><jats:p><jats:bold><jats:sc>patients and methods\u2002<\/jats:sc><\/jats:bold> Twenty\u2010three patients were studied. Seventeen subjects (Group A, 12 men, five women) were evaluated at baseline and after 1\u00a0year rhGH therapy (dose mean\u00a0\u00b1\u00a0SD: 0\u00b73\u00a0\u00b1\u00a00\u00b71\u00a0mg\/day) with the assessment of serum IGF\u2010I, ghrelin, ApN, leptin, insulin and glucose levels, percentage of body fat (BF%), HOMA\u2010IR and QUICKI. Seventeen age\u2010, sex\u2010 and body mass index (BMI)\u2010matched healthy subjects were recruited for comparisons. Six patients (Group B, three men, three women) underwent IGF\u2010I generation test (rhGH 0\u00b7025\u00a0mg\/kg\/day for 7\u00a0days), blood sampled at baseline and on day 8 for determination of IGF\u2010I, ghrelin and ApN levels.<\/jats:p><jats:p><jats:bold><jats:sc>results\u2002<\/jats:sc><\/jats:bold> Group\u2002A: at baseline GHD patients showed low IGF\u2010I levels and BF% significantly higher than controls (31\u00b74\u00a0\u00b1\u00a02\u00b75 <jats:italic>vs.<\/jats:italic> 26\u00b74\u00a0\u00b1\u00a01\u00b73, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Glucose, insulin, leptin, tryglicerides, low\u2010density lipoprotein (LDL) and high\u2010density lipoprotein (HDL) cholesterol levels, as well as HOMA\u2010IR and QUICKI values were similar in the two series, while total cholesterol levels were higher in GHD. In GHD, ghrelin levels were significantly lower than in controls (193\u00b79\u00a0\u00b1\u00a027\u00b71 <jats:italic>vs.<\/jats:italic> 298\u00b71\u00a0\u00b1\u00a032\u00b75 pmol\/l, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702), while ApN levels were similar (10\u00b72\u00a0\u00b1\u00a01\u00b71 and 9\u00a0\u00b1\u00a01\u00a0mg\/l, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a0ns). After 1\u00a0year of rhGH therapy, BF%, BMI, serum total and LDL cholesterol significantly decreased, serum leptin levels showed a trend to decrease, while HOMA\u2010IR and QUICKI did not change. Ghrelin and ApN levels significantly increased from 193\u00b79\u00a0\u00b1\u00a027\u00b71 to 232\u00b74\u00a0\u00b1 26\u00b73\u00a0pmol\/l (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) and from 8\u00b76\u00a0\u00b1\u00a00\u00b78 to 10\u00b73\u00a0\u00b1\u00a01\u00b71 mg\/l (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), respectively. In group B, the expected increase in IGF\u2010I levels was associated with a significant decrease in ghrelin levels, while ApN did not change.<\/jats:p><jats:p><jats:bold><jats:sc>conclusion\u2002<\/jats:sc><\/jats:bold> GHD patients showed serum ghrelin lower than controls, probably due to the higher BF%. No difference in ApN was observed. Ghrelin and ApN increments induced by long\u2010term treatment may be related to the significant BMI and BF% reduction that is the predominant metabolic effect of rhGH therapy. Conversely, the decrease in ghrelin levels observed after short\u2010term rhGH administration may be consistent with an inhibitory feedback of GH and\/or IGF\u2010I on ghrelin release.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02067.x","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T11:27:09Z","timestamp":1087903629000},"page":"81-87","source":"Crossref","is-referenced-by-count":34,"title":["Different effects of short\u2010 and long\u2010term recombinant hGH administration on ghrelin and adiponectin levels in GH\u2010deficient adults"],"prefix":"10.1111","volume":"61","author":[{"given":"Claudia","family":"Giavoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Cappiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Corbetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina L.","family":"Ronchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola S.","family":"Morpurgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Ferrante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Beck\u2010Peccoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Spada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)03197-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0255"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343763"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/jcem.86.10.7885","article-title":"Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin\u2010like immunoreactivity levels in humans","volume":"86","author":"Aryiasu H.","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021169"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200575200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.11.5176"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1470189"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1714"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1470065"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030713"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021683"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.2005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1340352"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0300-0664.2001.01456.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1210\/jcem.87.5.8624","article-title":"Serum adiponectin and leptin levels in patients with lipodystrophies","volume":"87","author":"Haque W.A.","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.6.1595"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450711"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.7.6661"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00940-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00362-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000048856.22331.50"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.01929.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1210\/jcem.87.6.8550","article-title":"Decreased plasma adiponectin concentrations in women with dyslipidemia","volume":"87","author":"Matsubara M.","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450669"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030513"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500663"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1210\/jcem.87.8.8879","article-title":"Insulin regulates plasma ghrelin concentration","volume":"87","author":"Saad M.F.","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/47.1.7"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.1.8129"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01789.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490331"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.4.707"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.5.7463"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/90984"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2004.02067.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2004.02067.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:54:33Z","timestamp":1697223273000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2004.02067.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,16]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1111\/j.1365-2265.2004.02067.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2004.02067.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,16]]}}}