{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:45:55Z","timestamp":1761518755750},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,6,16]],"date-time":"2004-06-16T00:00:00Z","timestamp":1087344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objectives\u2002<\/jats:sc><\/jats:bold> Mutation in <jats:italic>KCNE3<\/jats:italic> gene (Isk\u2010related family potassium voltage\u2010gated channel member 3 gene) was recently associated with the aetiology of thyrotoxic periodic paralysis (TPP). We studied 79 Chinese TPP patients by DNA sequencing of the entire coding sequence of <jats:italic>KCNE3<\/jats:italic> to determine if this gene is the cause of TPP in Chinese patients.<\/jats:p><jats:p><jats:bold><jats:sc>design and measurements\u2002<\/jats:sc><\/jats:bold> A case\u2013control genetic association study was carried out to determine the role of mutation\/polymorphism in <jats:italic>KCNE3<\/jats:italic> gene in the pathogenesis of TPP. Genomic DNA was extracted from peripheral blood samples. DNA sequencing was performed to cover the coding region of the <jats:italic>KCNE3<\/jats:italic> gene for the TPP subjects. Restriction fragment length polymorphism was used to genotype specific sequence variants.<\/jats:p><jats:p><jats:bold><jats:sc>subjects\u2002<\/jats:sc><\/jats:bold> Seventy\u2010nine TPP patients (cases) and 111 male thyrotoxic patients without history of paralysis (controls) were identified from thyroid clinic and during acute admission in a teaching hospital.<\/jats:p><jats:p><jats:bold><jats:sc>results\u2002<\/jats:sc><\/jats:bold> No pathogenic mutation in <jats:italic>KCNE3<\/jats:italic> was found in the TPP patients. The reported R83H mutation was also not found in the Chinese TPP patients. In addition, another silent polymorphism, 290T\/C, was also not associated with TPP.<\/jats:p><jats:p><jats:bold><jats:sc>conclusion\u2002<\/jats:sc><\/jats:bold> The results indicate that mutation in <jats:italic>KCNE3<\/jats:italic> is not a cause of TPP in Chinese patients.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02079.x","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T11:27:09Z","timestamp":1087903629000},"page":"109-112","source":"Crossref","is-referenced-by-count":25,"title":["No mutation in the <i>KCNE3<\/i> potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients"],"prefix":"10.1111","volume":"61","author":[{"given":"Nelson L. S.","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary T. C.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris H. L.","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. Q.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive S.","family":"Cockram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00207-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070191"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020698"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01481.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(96)00401-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(98)00141-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/89.6.463"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5538.451"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-17-12-1454"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021458"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-199209000-00006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000082392.66713.E3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X1994000400008"},{"key":"e_1_2_6_15_1","first-page":"609","article-title":"Conduction abnormalities in thyrotoxicosis: a report of three cases","volume":"22","author":"Yusoff K.","year":"1993","journal-title":"Annals of Academy of Medical Singapore"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2004.02079.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2004.02079.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:53:49Z","timestamp":1697223229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2004.02079.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,16]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1111\/j.1365-2265.2004.02079.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2004.02079.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,16]]}}}