{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:53:42Z","timestamp":1761742422515},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:00:00Z","timestamp":1094169600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objective\u2002<\/jats:sc><\/jats:bold> Adult GH deficiency (GHD) is linked to endothelial dysfunction and vascular disease. We examined the effect of 12\u00a0months of GH therapy on endothelial function, C\u2010reactive protein (CRP) and coronary risk.<\/jats:p><jats:p><jats:bold><jats:sc>design\u2002<\/jats:sc><\/jats:bold> Open\u2010design intervention study.<\/jats:p><jats:p><jats:bold><jats:sc>patients\u2002<\/jats:sc><\/jats:bold> Fourteen GH\u2010deficient patients (nonsmokers, without diabetes, hypertension or vascular disease) studied before, 6\u00a0months and 12\u00a0months after GH therapy.<\/jats:p><jats:p><jats:bold><jats:sc>measurements\u2002<\/jats:sc><\/jats:bold> Flow\u2010mediated dilatation (FMD), carotid intima\u2013media thickness (IMT) thrombomodulin (TM), E\u2010selectin, CRP, lipid profile, blood pressure and anthropometric data were recorded. We used the Framingham equation to calculate coronary risk.<\/jats:p><jats:p><jats:bold><jats:sc>results\u2002<\/jats:sc><\/jats:bold> FMD improved (7\u00b75\u00a0\u00b1\u00a01\u00b762 <jats:italic>vs<\/jats:italic>. 11\u00b793\u00a0\u00b1\u00a01\u00b752, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7038). Overall there was no change in IMT, TM, E\u2010selectin or CRP. The correlation between TM and FMD showed a trend for statistical significance (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b754, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.056). Changes in CRP correlated with change in IGF\u20101 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b767, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7012); E\u2010selectin correlated with high density lipoprotein (HDL)\u2010cholesterol (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b760, <jats:italic>P<\/jats:italic>\u00a0= 0\u00b7028), triglycerides (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b768, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) and waist\u2010to\u2010hip ratio (WHR) (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b771, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006). Systolic (127\u00b736\u00a0\u00b1\u00a04\u00b747 <jats:italic>vs<\/jats:italic>. 120\u00b736\u00a0\u00b1\u00a03\u00b750, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017) and diastolic (84\u00b771\u00a0\u00b1\u00a02\u00b773 <jats:italic>vs<\/jats:italic>. 76\u00b793\u00a0\u00b1\u00a02\u00b703, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005) blood pressure decreased. HDL\u2010cholesterol increased (0\u00b770\u00a0\u00b1\u00a00\u00b705 <jats:italic>vs<\/jats:italic>. 0\u00b793\u00a0\u00b1\u00a00\u00b706, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001). WHR decreased (0\u00b790\u00a0\u00b1\u00a00\u00b702 to 0\u00b788\u00a0\u00b1\u00a00\u00b702, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7043) without changes in weight or body mass index (BMI). Ten\u2010year absolute (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) and relative (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) cardiac risk decreased.<\/jats:p><jats:p><jats:bold><jats:sc>conclusion\u2002<\/jats:sc><\/jats:bold> Biophysical test of endothelial function (FMD) improved after 12\u00a0months of GH therapy but there was no significant change in biochemical endothelial or inflammatory markers. Calculated coronary risk decreased mainly due to reduction in systolic and diastolic blood pressure and increase in HDL\u2010cholesterol.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02109.x","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T09:49:22Z","timestamp":1094204962000},"page":"387-393","source":"Crossref","is-referenced-by-count":25,"title":["Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk"],"prefix":"10.1111","volume":"61","author":[{"given":"T. A. M.","family":"Abdu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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