{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:40:04Z","timestamp":1783485604046,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:00:00Z","timestamp":1094169600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objective\u2002<\/jats:sc><\/jats:bold> Surgical cure of Cushing's syndrome (CS) is followed by adrenocortical insufficiency, which may be long\u2010lasting. The aim was to elucidate recovery of adrenocortical function, defined as a normal cortisol response to ACTH stimulation, and the relation to ACTH in patients cured for CS due to pituitary Cushing's disease (CD) or adrenal (AA) adenomas.<\/jats:p><jats:p><jats:bold><jats:sc>design\u2002<\/jats:sc><\/jats:bold> A retrospective study including 32 patients considered surgically cured for CS (18\u00a0CD, 14 AA).<\/jats:p><jats:p><jats:bold><jats:sc>results\u2002<\/jats:sc><\/jats:bold> Twelve (67%) patients with CD recovered within median 24\u00a0months (range 7\u00a0months\u22124<jats:sup>1<\/jats:sup>\/<jats:sub>2<\/jats:sub> years) whereas six did not recover within 3\u201312\u00a0years. Plasma ACTH (p\u2010ACTH) at time of recovery was not different from p\u2010ACTH in patients not recovering (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b79). Eleven (79%) patients with AA recovered within 24\u00a0months (10\u00a0months\u22124\u00a0years) whereas three did not recover within 4\u201310\u00a0years. p\u2010ACTH at time of recovery was higher compared to patients not recovering (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b704). No differences were observed comparing CD and AA patients concerning preoperative 24\u2010h urinary free cortisol (UFC) excretion, postoperative unstimulated s\u2010cortisol or recovery time. By contrast, p\u2010ACTH measured at time of recovery was higher in AA compared to CD (median 12\u00b73 <jats:italic>vs.<\/jats:italic> 4\u00b76\u00a0pmol\/l) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), whereas plasma dehydroepiandrosterone sulfate (p\u2010DHEAS) was lower in AA compared to CD (median 300 <jats:italic>vs<\/jats:italic>. 1500\u00a0nmol\/l) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702).<\/jats:p><jats:p><jats:bold><jats:sc>conclusion\u2002<\/jats:sc><\/jats:bold> Recovery of secondary adrenal insufficiency is a slow process in both CD and AA. ACTH measured at time of recovery was significantly higher and DHEAS significantly lower in patients with AA compared to CD, which may suggest different mechanisms of the recovery process and different set points in the glucocorticoid feedback inhibition of ACTH secretion.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02111.x","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T09:49:22Z","timestamp":1094204962000},"page":"394-399","source":"Crossref","is-referenced-by-count":24,"title":["Characteristics of recovery of adrenocortical function after treatment for Cushing's syndrome due to pituitary or adrenal adenomas"],"prefix":"10.1111","volume":"61","author":[{"given":"Marianne","family":"Klose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars \u00d8stergaard","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-5-912"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.11.3114"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01261.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-4-604"},{"key":"e_1_2_6_6_1","first-page":"1085","article-title":"Time to recovery of the hypothalamic\u2013pituitary\u2013adrenal axis after curative resection of adrenal tumors in patients with Cushing's syndrome","volume":"108","author":"Doherty G.M.","year":"1990","journal-title":"Surgery"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-2-413"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.1.173"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-1-11"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200107000-00013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054524"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655102753517181"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-47-2-272"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1985.tb01096.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.614436.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119487"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5250"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01511.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10339"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb00975.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1984.tb00078.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0300-0664.2001.01444.x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2004.02111.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2004.02111.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:25:13Z","timestamp":1697221513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2004.02111.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1111\/j.1365-2265.2004.02111.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2004.02111.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}