{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:10:16Z","timestamp":1784988616689,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,15]],"date-time":"2004-10-15T00:00:00Z","timestamp":1097798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold><jats:sc>objective<\/jats:sc>\u2002<\/jats:bold> Vitamin D deficiency and osteomalacia remain commonplace within the Asian community in Bradford. The treatment of vitamin D deficiency and osteomalacia is cheap and effective, but there are few data on long\u2010term outcomes. Studies have suggested that a minority of patients fail to normalize parathyroid hormone (PTH) levels during therapy with vitamin D. This study aimed to determine what proportion of Asian patients with vitamin D deficiency and secondary hyperparathyroidism normalize PTH levels following therapy with oral vitamin D and to examine reasons for failure to normalize PTH.<\/jats:p><jats:p><jats:bold><jats:sc>design<\/jats:sc>\u2002<\/jats:bold> This study examined the impact of an oral regimen of vitamin D 800\u00a0i.u. (20 micrograms) and calcium 1000\u00a0mg daily, on PTH levels within an endocrinology outpatient clinic.<\/jats:p><jats:p><jats:bold><jats:sc>patients<\/jats:sc>\u2002<\/jats:bold> 51 (4M:47F) Asian patients, median age 39\u00a0years (range 16\u201377 years) with vitamin D deficiency (25\u2010hydroxyvitamin D\u00a0&lt;\u00a025\u00a0nmol\/l) and secondary hyperparathyroidism (PTH\u00a0&gt;\u00a05\u00b77\u00a0pmol\/l).<\/jats:p><jats:p><jats:bold><jats:sc>measurements<\/jats:sc>\u2002<\/jats:bold> All patients had at least one follow\u2010up measurement of PTH and calcium during treatment. A subgroup of patients gave consent for examination of GP\u2010prescribing records to indirectly asses adherence to therapy.<\/jats:p><jats:p><jats:bold><jats:sc>results<\/jats:sc>\u2002<\/jats:bold> PTH normalized in only 28\/51 (55%) patients (group N) and failed to normalize in 23\/51 (45%) patients (group F). Baseline patient characteristics including: age, basal serum 25\u2010hydroxyvitamin D (25OHD), basal serum PTH, basal serum calcium and post treatment serum calcium, were similar in groups N and F. Mild hypercalcaemia occurred in only two (3\u00b79%) patients. The proportion of prescriptions collected by patients in group N was 75 (17\u2013100)% and in group F was 17 (0\u2013100)%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001.<\/jats:p><jats:p><jats:bold><jats:sc>conclusions<\/jats:sc>\u2002<\/jats:bold> This study has demonstrated that long\u2010term oral treatment with vitamin D and calcium, fails to normalize PTH in a significant proportion of patients with vitamin D deficiency and osteomalacia. This is most likely related to lack of adherence to long\u2010term treatment. Improved ways of treating this condition need to be explored.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02139.x","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T12:47:32Z","timestamp":1099399652000},"page":"603-606","source":"Crossref","is-referenced-by-count":7,"title":["Failure to normalize parathyroid hormone during treatment of vitamin D deficiency in Asian patients"],"prefix":"10.1111","volume":"61","author":[{"given":"Steven R.","family":"Peacey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Harries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/8.1.52"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7171.1466"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-3-535"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/003693306200700402"},{"key":"e_1_2_6_6_1","first-page":"439","article-title":"Clinical and histological spectrum of osteomalacia among Asians in south London","volume":"83","author":"Finch P.J.","year":"1992","journal-title":"Quarterly Journal of Medicine"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5815.677"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.12.939"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.5.423"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg354"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.4.0437"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78933-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0780383"},{"key":"e_1_2_6_14_1","first-page":"123","volume-title":"Dietary Reference Values for Food Energy and Nutrients for the United Kingdom.","author":"Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy.","year":"1991"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.97.7.322"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.7.3086"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.73.866.813"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2004.02139.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2004.02139.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T19:13:56Z","timestamp":1697224436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2004.02139.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,15]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.1365-2265.2004.02139.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2004.02139.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,15]]}}}