{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:28:59Z","timestamp":1771666139366,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T00:00:00Z","timestamp":1101686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold><jats:sc>objective\u2002<\/jats:sc><\/jats:bold> In Graves\u2019 ophthalmopathy (GO) intercellular adhesion molecule\u20101 (ICAM\u20101) is thought to play a key role in lymphocyte infiltration into the orbit, and serum levels of its soluble form are positively correlated to clinical activity score (CAS). Serum antibodies against collagen\u00a0XIII (CollXIIIAb), a plasma membrane protein expressed at a low level in almost all connective tissue\u2010producing cells, have been detected in GO, but their significance is unclear. The aim of this study was to search for CollXIIIAb in Graves\u2019 patients with and without ophthalmopathy and to correlate their levels with CAS and with serum soluble ICAM\u20101 (sICAM\u20101) values.<\/jats:p><jats:p><jats:bold><jats:sc>patients\u2002<\/jats:sc><\/jats:bold> We studied 66 patients with Graves\u2019 disease whose sera had been previously tested for sICAM\u20101 levels, grouped as follows: 28 with moderate and active ophthalmopathy (group\u00a01), 12 of them hyperthyroid (group\u00a01a) and 16 euthyroid (group\u00a01b); 13 with mild and inactive ophthalmopathy and normal thyroid function (group\u00a02); 25 without ophthalmopathy (group\u00a03), 11 of them hyperthyroid (group\u00a03a) and 14 euthyroid (group\u00a03b). Finally, 26 sera of normal controls were studied.<\/jats:p><jats:p><jats:bold><jats:sc>measurements\u2002<\/jats:sc><\/jats:bold> CollXIIIAb were evaluated by an enzyme\u2010linked immunosorbent assay (ELISA) method.<\/jats:p><jats:p><jats:bold><jats:sc>results\u2002<\/jats:sc><\/jats:bold> In group\u00a01 patients, CollXIIIAb were detected at high levels in 8\/12\u00a0(66\u00b76%) in group\u00a01a [optical density (OD) ranging from 0\u00b7529 to 0\u00b7894] and in 10\/16\u00a0(62\u00b75%) in group\u00a01b (OD 0\u00b7560\u20130\u00b7855). In group\u00a02 patients, CollXIIIAb were detected but at low levels (OD 0\u00b7205\u20130\u00b7260) in 4\/13 patients\u00a0(30\u00b77%). In group\u00a03 patients, CollXIIIAb were present at low levels in 6\/11\u00a0(54\u00b75%) of group\u00a03a and in 5\/14\u00a0(35\u00b77%) of group\u00a03b (OD 0\u00b7215\u20130\u00b7290 and 0\u00b7144\u20130\u00b7245, respectively). CollXIIIAb were detected in only 4\/26 normal controls (15%) but at low levels (OD 0\u00b7150\u20130\u00b7185). CollXIIIAb values in both groups\u00a01a and 1b were significantly higher than those of the remaining groups. A positive correlation between CollXIIIAb levels and CAS but not thyroid hormone levels was found in groups\u00a01a, 1b and 2. Moreover, a positive correlation between CollXIIIAb levels and sICAM\u20101\u2010values was also evidenced in all three groups.<\/jats:p><jats:p><jats:bold><jats:sc>conclusions\u2002<\/jats:sc><\/jats:bold> Our results suggest that CollXIIIAb could be considered as a further good marker of active inflammatory processes involving the adipose connective tissue in GO. In particular, the high levels of CollXIIIAb in sera of Graves\u2019 patients with active ophthalmopathy could reflect an increased expression of type XIII collagen on the membrane of activated fibroblasts in these patients. Thus, the evaluation of these antibodies could be added to other known markers as a useful and inexpensive tool in monitoring Graves\u2019 patients and in modulating the treatment of GO.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02167.x","type":"journal-article","created":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T09:40:52Z","timestamp":1105004452000},"page":"24-29","source":"Crossref","is-referenced-by-count":32,"title":["Serum antibodies to collagen\u00a0XIII: a further good marker of active Graves\u2019 ophthalmopathy"],"prefix":"10.1111","volume":"62","author":[{"given":"A.","family":"De Bellis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sansone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Coronella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Conte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Perrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bellastella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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