{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:01:13Z","timestamp":1761894073383},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T00:00:00Z","timestamp":1103673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background and objective\u2002<\/jats:bold> Women with previous gestational diabetes (pGDM) are at risk of developing Type 2 diabetes. Glucagon\u2010like peptide\u20101 (GLP\u20101) potentiates the insulin response to oral glucose, and its secretion is diminished in Type 2 diabetes. The aim of the study was to see if decreased GLP\u20101 secretion might be an early abnormality in the progression to Type 2 diabetes and would therefore be diminished in women with pGDM.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> Eleven women with pGDM and previously documented normal glucose tolerance and 11 control women underwent a 75 g oral glucose tolerance test (OGTT). Circulating plasma glucose, insulin, nonesterified fatty acids (NEFA) and GLP\u20101 concentrations were sampled.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> One of the women with pGDM had impaired glucose tolerance and was excluded from the study. All other women had normal glucose tolerance. The women with pGDM had higher fasting glucose concentrations than controls (5\u00b71; 4\u00b79\u20135\u00b73 <jats:italic>vs.<\/jats:italic> 4\u00b78; 4\u00b74\u20135\u00b71\u00a0mmol\/l, median; interquartile range, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704) and greater circulating glucose area under the curve (AUC) following the oral glucose load (930; 818\u20131015 <jats:italic>vs.<\/jats:italic> 668; 584\u2013737\u00a0min\u00a0\u00d7\u00a0mmol\/l, <jats:italic>P<\/jats:italic>\u00a0= 0\u00b70007). Fasting insulin concentrations and total insulin AUC were similar. The initial (0\u201330\u00a0min) insulin response was decreased in the pGDM women (AUC 3981; 2783\u20134795 <jats:italic>vs.<\/jats:italic> 6167; 5009\u20138145\u00a0min\u00a0\u00d7 pmol\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705). The initial (0\u201330\u00a0min) GLP\u20101 response was reduced in the pGDM women (AUC 816; 663\u2013984 <jats:italic>vs.<\/jats:italic> 1163; 872\u20132024\u00a0min\u00a0\u00d7\u00a0pmol\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> A reduced initial GLP\u20101 response to oral glucose may therefore be an early abnormality in the progression to Type 2 diabetes.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02172.x","type":"journal-article","created":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T09:40:52Z","timestamp":1105004452000},"page":"51-55","source":"Crossref","is-referenced-by-count":16,"title":["Impaired circulating glucagon\u2010like peptide\u20101 response to oral glucose in women with previous gestational diabetes"],"prefix":"10.1111","volume":"62","author":[{"given":"Shareen","family":"Forbes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May","family":"Moonan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Anyaoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin G.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A.","family":"Ghatei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond G.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.4.0336"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(01)00315-1"},{"key":"e_1_2_6_4_2","volume-title":"Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. 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