{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:35:46Z","timestamp":1778924146987,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T00:00:00Z","timestamp":1102032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Osteoporosis is a growing health problem in males as well as in females. Sex hormones and insulin\u2010like growth factor\u2010I (IGF\u2010I) have been shown to be the major determinants in male bone metabolism. Osteoprotegerin (OPG) is a recently identified cytokine that acts as a decoy receptor for the receptor activator of NF\u2010\u03baB ligand (RANKL). OPG and RANKL have been shown to be important regulators of osteoclastogenesis. However, the relationship between the OPG\u2010RANKL system and male bone status in human populations are unclear. Thus, the aim of this study was to investigate the relationship between the OPG\u2010RANKL system and bone mineral metabolism in males.<\/jats:p><jats:p><jats:bold>Patients and Measurements\u2002<\/jats:bold> Serum concentrations of OPG, RANKL, oestradiol, total testosterone and IGF\u2010I and bone mineral density (BMD) were measured in 80 Korean males aged 42\u201370 (mean age, 54\u00b75\u00a0year). Enzyme\u2010linked immunosorbent assays were used to determine the serum concentrations of OPG and RANKL. Serum concentrations of oestradiol, total testosterone, IGF\u2010I and bone turnover markers were determined using standard methods. BMD at the lumbar spine and femoral neck were measured by dual energy X\u2010ray absorptiometry.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We observed a significant negative correlation between the serum OPG levels and lumbar spine BMD (<jats:italic>r<\/jats:italic>\u00a0=\u22120\u00b7259, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) in Spearman correlation analysis. Serum OPG levels and RANKL\/OPG ratios were found to be significantly correlated to the serum osteocalcin levels (<jats:italic>r<\/jats:italic>\u00a0=\u2212\u00a00\u00b7254, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705; <jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b7264, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) in Spearman correlation analysis. Serum OPG levels were found to be negatively correlated with serum oestradiol levels (<jats:italic>r<\/jats:italic>\u00a0=\u22120\u00b7319, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) in Spearman correlation analysis. In addition, a significant positive correlation was found between serum RANKL\/OPG ratios and oestradiol levels (<jats:italic>r<\/jats:italic>\u00a0= 0\u00b7374, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) in Spearman correlation analysis. In contrast, Serum total testosterone and IGF\u2010I levels were not correlated with serum OPG levels or RANKL to OPG ratios in Spearman correlation analysis. In a multiple regression analysis, age, body mass index (BMI), and serum OPG levels were identified as a significant predictor for lumbar spine BMD, and age, BMI, serum OPG and RANKL levels for femoral neck BMD. In another multiple regression analysis, only serum oestradiol level was identified as a significant predictor for serum OPG or RANKL levels. In contrast, Serum total testosterone and IGF\u2010I levels were not correlated with serum OPG or RANKL levels in multiple regression analysis.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our data show that the circulating OPG\u2010RANKL system is associated with bone metabolism in the male populations. Also, our data suggest that OPG and RANKL may be mediators of the effects of oestradiol in male bone metabolism.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02179.x","type":"journal-article","created":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T09:40:52Z","timestamp":1105004452000},"page":"92-98","source":"Crossref","is-referenced-by-count":57,"title":["Circulating osteoprotegerin and receptor activator of NF\u2010\u03baB ligand system are associated with bone metabolism in middle\u2010aged males"],"prefix":"10.1111","volume":"62","author":[{"given":"Ki Won","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jung","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun 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