{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:50:38Z","timestamp":1791298238708,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,12,23]],"date-time":"2004-12-23T00:00:00Z","timestamp":1103760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction\u2002<\/jats:bold>\n                    The treatment of craniopharyngiomas is associated with long\u2010term morbidity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim of the study\u2002<\/jats:bold>\n                    To assess the long\u2010term functional outcome and mortality rates after treatment for craniopharyngiomas, we audited our data with special focus on cardiovascular, neurological and psychosocial morbidity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods\u2002<\/jats:bold>\n                    Between 1965 and 2002, 54 consecutive patients underwent surgery for craniopharyngiomas at the Leiden University Medical Centre (LUMC). Fifteen patients (25%) received additional postoperative radiation therapy. The median follow\u2010up period was 10\u00a0years (range 1\u201337\u00a0years).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Long\u2010term cure rate was 82% and long\u2010term recurrence rate 18%. Visual fields\/visual acuity stabilized or improved in 74% of cases. The long\u2010term prevalence rate of hypopituitarism was 89%. In addition, long\u2010term cardiovascular, neurological and psychosocial morbidity rates were high: 22% (risk factors 57%), 49% and 47%, respectively. Female sex was an independent predictor of increased cardiovascular, neurological and psychosocial morbidity (odds ratio 3\u00b778,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7031). Ten patients (18%) died during an 828\u00a0person\u2010year follow\u2010up. The actuarial patient survival rates 5, 10 and 20\u00a0years after the initial operation were 95, 85 and 85%, respectively. The standardized mortality ratio (SMR) was 2\u00b788 [95% confidence interval (CI) 1\u00b735\u20134\u00b799].\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    Craniopharyngioma is associated with excessive long\u2010term multisystem morbidity and mortality, especially in female patients, despite a high cure rate. These observations indicate that dedicated long\u2010term follow\u2010up of these patients is required. The purpose of the follow\u2010up should be: first, to look for recurrences and to ensure appropriate endocrine replacement, especially oestrogen replacement in premenopausal females; and second, to achieve intensive control of glucose, lipids, blood pressure and weight, as in any other patient with increased risk for cardiovascular disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2265.2004.02196.x","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T11:32:16Z","timestamp":1106652736000},"page":"197-204","source":"Crossref","is-referenced-by-count":190,"title":["High prevalence of long\u2010term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma"],"prefix":"10.1111","volume":"62","author":[{"given":"Alberto M.","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.","family":"Schutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan H. 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