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All patients were first operated on and successively irradiated at a dose of 45\u201350\u00a0Gy in 25\u201328 fractions for persistent (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) or recurrent (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) disease.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Long\u2010term GH\/IGF\u2010I secretion and local tumour control were evaluated regularly, and possible side\u2010effects were searched for systematically, especially in terms of secondary endocrine dysfunction. Biochemical cure of acromegaly was defined by glucose\u2010suppressed plasma GH levels below 1\u00a0\u00b5g\/l during an oral glucose tolerance test (OGTT) and normal age\u2010corrected IGF\u2010I values.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The 5\u2010, 10\u2010 and 15\u2010year overall survival rates were 98%, 95% and 93%, respectively. Suppression of GH during OGTT was seen in 9% of patients at 2\u00a0years, 29% at 5\u00a0years, 52% at 10\u00a0years, and 77% at 15\u00a0years. Age\u2010corrected IGF\u2010I levels were normal in 8% of patients 2\u00a0years after RT, and this proportion increased to 23%, 42% and 61% after 5, 10 and 15\u00a0years, respectively. Normalization of GH\/IGF\u2010I mainly depended on pre\u2010RT levels. Local tumour control was 95% at 5, 10 and 15\u00a0years after treatment. Late toxicity was mainly represented by progressive hypopituitarism, which was present in 33% of patients at baseline and increased to 57%, 78% and in 85% of patients at 5 10 and 15\u00a0years after RT, respectively.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Conventional RT is effective in the long\u2010term control of GH\u2010secreting pituitary adenomas, although with a high prevalence of progressive hypopituitarism. At present, it remains a suitable option in acromegalic patients uncontrolled by surgery or medical therapy.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2005.02199.x","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T16:32:16Z","timestamp":1106670736000},"page":"210-216","source":"Crossref","is-referenced-by-count":102,"title":["The long\u2010term efficacy of conventional radiotherapy in patients with GH\u2010secreting pituitary adenomas"],"prefix":"10.1111","volume":"62","author":[{"given":"Giuseppe","family":"Minniti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Lise","family":"Jaffrain\u2010Rea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Osti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Solda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Tamburrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo Maurizi","family":"Enrici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004053221405"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0022"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.10.3419"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01679.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031199"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031584"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-011841"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0100611"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01343.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.9.3034"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.2.527"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.6.2779"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2001-012012"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.9.2768"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2001-011913"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1210\/jcem.85.10.6870","article-title":"Hormonal and metabolic effects of radiotherapy in acromegaly: long\u2010term results in 128 patients followed in a single center","volume":"85","author":"Barrande G.","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.7.2476"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.5.2068"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.10.3187"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1380160"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450717"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01704.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01705.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01706.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1300581"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345491"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00029-6"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.2.0287"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.6.1282"},{"key":"e_1_2_5_31_2","unstructured":"Arafah B.M. 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