{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:42:21Z","timestamp":1784248941024,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,17]],"date-time":"2005-01-17T00:00:00Z","timestamp":1105920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Patients with acromegaly are at moderately increased risk of developing colorectal cancer and may be considered for screening colonoscopy. In turn, large bowel dimensions may be increased in these patients, factors that predict for increased risk of serious complications such as perforation.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate this risk potential, we measured large bowel length and loop complexity using magnetic endoscopic imaging (MEI).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Case\u2013control study in 25 unselected patients with acromegaly (mean age 56\u00a0years) <jats:italic>vs.<\/jats:italic> 41 nonacromegalic controls (mean age 60\u00a0years) undergoing screening colonoscopy.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> MEI parameters were determined and age\u2010 and sex\u2010adjusted mean differences calculated. The dependency of total large bowel length on various demographic and disease\u2010related factors (e.g. GH exposure, IGF\u2010I and IGFBP\u20103 concentrations) was assessed using regression techniques.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Total large bowel length was increased by 20%[95% confidence interval (CI) 9\u201331%] in patients with acromegaly compared with controls (unadjusted and adjusted; <jats:italic>P<\/jats:italic>\u2010values &lt;\u00a00\u00b7001). Acromegaly was also associated with increased time taken to reach the caecum (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b701) and increased pelvic loop complexities (5\/25 <jats:italic>vs.<\/jats:italic> 1\/41, Fisher's exact test: <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703). Total large bowel length was predicted by age at colonoscopy (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7003) and patient height (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b703), but not by surrogate biochemical markers of disease activity.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Acromegaly is associated with increased large bowel length and loop complexity making colonoscopy technically challenging, and theoretically increasing the risk of serious complications. Patients need to be counselled accordingly, and appropriate resources with experienced staff allocated.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2005.02217.x","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T10:39:36Z","timestamp":1109241576000},"page":"323-330","source":"Crossref","is-referenced-by-count":20,"title":["Determination of large bowel length and loop complexity in patients with acromegaly undergoing screening colonoscopy"],"prefix":"10.1111","volume":"62","author":[{"given":"Andrew G.","family":"Renehan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Painter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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