{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:02:12Z","timestamp":1770062532979,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T00:00:00Z","timestamp":1110931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hypopituitary patients have an increased risk of vascular mortality that may relate to growth hormone deficiency (GHD). We investigated the effects of 6\u00a0months of GH therapy on large\u2010 and small\u2010artery function and high\u2010sensitivity C\u2010reactive protein (hsCRP) in a cohort of GH\u2010deficient patients. Sixteen hypopituitary patients were randomized to 6\u00a0months of GH therapy or no treatment, then vice versa. hsCRP, 24\u2010h blood pressure (BP) and pulse wave velocity (PWV) were measured and resistance arteries were used to construct concentration\u2013response curves to endothelium\u2010dependent and \u2010independent agents. GH therapy increased IGF\u20101 from 60\u00a0\u00b1\u00a07\u00b72 to 167\u00a0\u00b1\u00a016\u00b72\u00a0\u00b5g\/l [confidence interval (CI) 94\u00b79, 138\u00b78, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001]. hsCRP declined after 6\u00a0months of GH from 3\u00b78\u00a0\u00b1\u00a00\u00b788 to 2\u00b70\u00a0\u00b1\u00a00\u00b749\u00a0mg\/l (CI 0\u00b773, 3\u00b757, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006). Mean arterial BP fell from 91\u00b77\u00a0\u00b1\u00a01\u00b75 to 89\u00b73\u00a0\u00b1\u00a01\u00b72\u00a0mmHg (CI 0\u00b781, 4\u00b707, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005), as did PWV (8\u00b71\u00a0\u00b1\u00a00\u00b74 to 6.7\u00a0\u00b1\u00a00\u00b75\u00a0m\/s). The decline in PWV correlated with the decline in hsCRP (<jats:italic>r<\/jats:italic>\u00a0= 0\u00b768, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701). Resistance artery function was unchanged after GH therapy. GH replacement may lead to differentially altered production of vasorelaxant agents from the endothelium of large and small arteries. Reduction in vascular inflammation may be associated with reduced vascular risk.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2005.02245.x","type":"journal-article","created":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T11:31:27Z","timestamp":1111663887000},"page":"473-479","source":"Crossref","is-referenced-by-count":34,"title":["Growth hormone replacement reduces C\u2010reactive protein and large\u2010artery stiffness but does not alter endothelial function in patients with adult growth hormone deficiency"],"prefix":"10.1111","volume":"62","author":[{"given":"Roland W.","family":"McCallum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A. R.","family":"Sainsbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Spiers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna F.","family":"Dominiczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Petrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M. C.","family":"Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91812-O"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1169"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00650.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-1-39"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.7.2448"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.6.1290"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01002.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(95)90004-7"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/jcem.82.5.3951","article-title":"Increased arterial intima\u2013media thickness in childhood\u2010onset growth hormone deficiency","volume":"82","author":"Capaldo B.","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.10.4657"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.2.309"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1055\/s-0038-1650594","article-title":"Long\u2010term treatment with growth hormone decreases plasminogen activator inhibitor\u20101 and tissue plasminogen activator in growth hormone\u2010deficient adults","volume":"76","author":"Johansson J.\u2010O.","year":"1996","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-6374(99)80006-9"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.8.731"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-2-200007180-00010"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01832.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040019"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000099844.31524.05"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1210\/jcem.87.2.8199","article-title":"Altered vascular function in young women with polycystic ovary syndrome","volume":"87","author":"Kelly C.J.","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_7_24_2","first-page":"968","article-title":"Insulin\u2010like growth factor acts as a NO\u2010dependent vasodilator in normotensive but not hypertensive rat arteries","volume":"38","author":"McCallum R.W.","year":"2001","journal-title":"Hypertension"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb02556.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010193431603"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.7.3309"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01514.x"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095031.51492.C5"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS19990166"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.8.1027"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.6.1881"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4223"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1470333"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000033116.22237.F9"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030713"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022273"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2005.02245.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2005.02245.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:32:05Z","timestamp":1697232725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2005.02245.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,16]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1111\/j.1365-2265.2005.02245.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2005.02245.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,16]]}}}