{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:51Z","timestamp":1785773511052,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T00:00:00Z","timestamp":1127952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Primary hyperparathyroidism (PHPT) and vitamin\u00a0D insufficiency are common conditions that can occur in combination. However, low plasma 25\u2010hydroxyvitamin\u00a0D (25OHD) may also enhance the risk of PHPT or modify disease severity.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare the risk of vitamin\u00a0D insufficiency and deficiency stratified by age, sex and season between PHPT patients and controls and to assess associations between plasma 25OHD and adenoma weight, biochemical variables, bone mineral density (BMD) and clinical complications.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Cross\u2010sectional study.<\/jats:p><jats:p><jats:bold>Material\u2002<\/jats:bold> A total of 289 consecutive Caucasian patients with PHPT aged 65\u00b79 (24\u201392) years, 289 sex\u2010, age\u2010 and season\u2010matched normocalcaemic controls and 187 healthy adult blood donors. PHPT diagnosis was confirmed in 214 by neck exploration.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Vitamin\u00a0D insufficiency (plasma 25OHD\u00a0&lt;\u00a050\u00a0nmol\/l) was observed in 81% of PHPT patients compared with 60% of sex\u2010 and age\u2010matched controls (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001) and 35% of blood donors (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001). During summer, 77%<jats:italic>vs.<\/jats:italic> 53% (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001) and 4% (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001), respectively, had vitamin\u00a0D insufficiency. Average plasma 25OHD was 41\u00a0(range 9\u201387)\u00a0nmol\/l among 27 PHPT patients compared with 87\u00a0(21\u2013173)\u00a0nmol\/l (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001) among aged\u2010matched blood donors. During winter, 86%<jats:italic>vs.<\/jats:italic> 66% (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001) and 71% (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b705), respectively, had vitamin\u00a0D insufficiency. Vitamin\u00a0D deficiency (plasma 25OHD\u00a0&lt;\u00a025\u00a0nmol\/l) was observed in 33% of PHPT patients compared with 20% of age\u2010 and sex\u2010matched controls (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001) and 13% of blood donors (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001). Both PHPT patients and controls showed seasonal variations in 25OHD related to the average number of sun hours, but values were lower in PHPT patients at all calendar months. In PHPT patients low plasma 25OHD was associated with higher plasma levels of calcium, PTH and alkaline phosphatase and with lower renal calcium excretion, femoral neck and forearm BMD. No association was found between plasma 25OHD and adenoma weight (total or divided into tertiles). There was a trend towards increased risk of osteoporotic fractures (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b708) with low plasma 25OHD.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Vitamin\u00a0D insufficiency and deficiency are common findings in PHPT and occur more often than in a sex\u2010 and age\u2010matched control group referred from general practice and in normal blood donors irrespective of season. Low plasma 25OHD levels are associated with an aggravated clinical presentation of PHPT but do not affect adenoma size.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2005.02371.x","type":"journal-article","created":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T15:26:23Z","timestamp":1128007583000},"page":"506-513","source":"Crossref","is-referenced-by-count":146,"title":["Vitamin\u00a0D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism"],"prefix":"10.1111","volume":"63","author":[{"given":"B.","family":"Moosgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Heickendorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Melsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mosekilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.4.0437"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-7-505"},{"key":"e_1_2_5_4_2","unstructured":"Ooms M.E.(1994)Osteoporosis in elderly women: vitamin D deficiency and other risk factors.PhD Thesis.Vrije University Amsterdam."},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100806"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050030"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050219"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00866-9"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021064"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78933-9"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912283212602"},{"key":"e_1_2_5_12_2","unstructured":"Glerup H.(1999)Investigations on the role of vitamin D in muscle function \u2013 a study of muscle function in vitamin D deficient humans and the effect of treatment with vitamin D.PhD Thesis.Aarhus University Denmark."},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012068700-8\/50012-8"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2001345"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90812-2"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00294-6"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6622-z"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.10.3541"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1997.tb03094.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1210\/jcem.87.5.8475","article-title":"Seasonal changes in calciotropic hormones, bone markers, and bone mineral density in elderly women","volume":"87","author":"Rapuri P.B.","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1566-1"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6693.236"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02043.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.3.1054"},{"key":"e_1_2_5_25_2","first-page":"375","volume-title":"The Parathyroids. 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