{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:36:40Z","timestamp":1777459000631,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T00:00:00Z","timestamp":1139443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Apolipoprotein E (<jats:italic>APOE<\/jats:italic>) genotype is a regulator of hepatic lipoprotein metabolisms and has been linked with longevity. The relationship between <jats:italic>APOE<\/jats:italic> genotype and plasma C\u2010reactive protein (CRP), which is produced by the liver during inflammation, has not been studied in nonagenarians. The aim of the present study was to establish whether <jats:italic>APOE<\/jats:italic> genotype is related to plasma concentrations of CRP and lipids, or longevity among nonagenarians.<\/jats:p><jats:p><jats:bold>Design and patients\u2002<\/jats:bold> This cross\u2010sectional study consisted of 291 Finnish nonagenarians and three previously described and genotyped control populations from the same area (i.e. newborns, 40\u2010year\u2010olds, and 70\u2010year\u2010olds).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In all nonagenarians and especially in women (<jats:italic>P<\/jats:italic>= 0.038), CRP level decreased linearly in the genotype order of \u025b2\/2, \u025b2\/3, \u025b3\/3, \u025b2\/4, \u025b3\/4 and \u025b4\/4. Total (<jats:italic>P<\/jats:italic>= 0.009) and low\u2010density lipoprotein (LDL) cholesterol (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.076) levels, in turn, were increased in the \u025b4 allele carriers. In newborns, the \u025b4 frequency was 0.192, in 40\u2010year\u2010olds 0.181, in 70\u2010year\u2010olds 0.179 and in nonagenarians 0.095 (<jats:italic>P<\/jats:italic> &lt; 0.0001). The decrease in the \u025b4 allele frequency in the elderly was more clearly seen in women than in men.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>  <jats:italic>APOE<\/jats:italic>\u025b4 allele seems to be associated with decreased inflammatory response as measured by CRP among nonagenarians. This finding may partly explain why some \u025b4 allele carriers can reach very old age despite increased risk of hypercholesterolaemia.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02455.x","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T16:14:33Z","timestamp":1139501673000},"page":"265-270","source":"Crossref","is-referenced-by-count":46,"title":["Apolipoprotein E genotype is related to plasma levels of C\u2010reactive protein and lipids and to longevity in 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