{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T07:48:33Z","timestamp":1697269713655},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T00:00:00Z","timestamp":1139443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Serum osteocalcin is a marker of bone formation. The concentration of osteocalcin is decreased with tissue injury. As glucocorticoids are known both to be increased in this situation and to diminish serum osteocalcin, we have hypothesized that they could be involved in this decrease.<\/jats:p><jats:p><jats:bold>Design and patients\u2002<\/jats:bold> We compared osteocalcin levels in two groups of patients undergoing abdominal surgery, one receiving thiopental, and the other etomidate, a glucocorticoid synthesis blocker. For comparative reasons, another protein decreased by glucocorticoids (osteoprotegerin) was measured in patients anaesthetized with thiopental.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Serum osteocalcin, cortisol and albumin were determined before and over the 24\u00a0h following surgery. Serum concentration of osteoprotegerin (OPG) and receptor activator of the nuclear factor \u03baB ligand (RANKL) were also determined before and 24\u00a0h after surgery in a third group of nine patients who received thiopental for anaesthetic induction.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Cortisol levels were increased in the thiopental group, whereas, as expected, were decreased in etomidate patients. However, serum osteocalcin concentration decreased in a similar way in both groups. Serum OPG and RANKL levels were within the normal range at baseline and did not significantly change after surgery.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The decrease in serum osteocalcin induced by tissue injury is independent of the increase in cortisol secretion triggered by the latter. In addition, another pharmacologically proven effect of cortisol on bone metabolism, OPG inhibition, could not be demonstrated in the first 24\u00a0h following surgery, in spite of the physiological increase in endogenous cortisol secretion taking place in this period.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02457.x","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T16:14:33Z","timestamp":1139501673000},"page":"280-283","source":"Crossref","is-referenced-by-count":0,"title":["Factors other than glucocorticoids are involved in the osteoblast activity decrease caused by tissue injury"],"prefix":"10.1111","volume":"64","author":[{"given":"J. M.","family":"Olmos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Amado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Valero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gonz\u00e1lez\u2010Mac\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(85)90326-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-6009(08)80013-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6143403"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04204.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90008-7"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842187"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405313102202"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1986.tb02376.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/83.3.461"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2002.02450.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.7.2355"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1590191"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.3.479"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180513"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06941.x"},{"key":"e_1_2_6_18_2","first-page":"1596","article-title":"Tumor necrosis factor\u2010\u03b1 inhibits 1,25\u2010dihydroxyvitamin D3\u2010stimulated bone Gla protein synthesis in rat osteosarcoma cells (ROS 17\/2\u00b78) by a pretranslational mechanism","volume":"121","author":"Names M.S.","year":"1987","journal-title":"Endocrinology"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92243-2"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650020612"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000054586"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2006.02457.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2006.02457.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T20:11:37Z","timestamp":1697227897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2006.02457.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,9]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1365-2265.2006.02457.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02457.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,9]]}}}