{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:01:23Z","timestamp":1793235683801,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T00:00:00Z","timestamp":1140566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of this study was to assess the role of pulsed tissue Doppler (TD) to identify left (LV) and right ventricular (RV) myocardial regional involvement in acromegaly.<\/jats:p><jats:p><jats:bold>Patients and measurements\u2002<\/jats:bold> Thirty active acromegaly patients, free of diabetes mellitus, thyroid dysfunction, valvular and coronary heart disease, clinically overt heart failure, and 30 sex\u2010 and age\u2010matched healthy controls underwent standard Doppler echocardiography and pulsed TD, by placing the sample volume at the level of basal posterior septum, LV lateral mitral annulus and RV lateral tricuspid annulus. Myocardial systolic (S<jats:sub>m<\/jats:sub>) and diastolic velocities (E<jats:sub>m<\/jats:sub>\/A<jats:sub>m<\/jats:sub> ratio) and time\u2010intervals of relaxation (RT<jats:sub>m<\/jats:sub>), precontraction (PCT<jats:sub>m<\/jats:sub>) and contraction (CT<jats:sub>m<\/jats:sub>) and the PCT<jats:sub>m<\/jats:sub>\/CT<jats:sub>m<\/jats:sub> ratio were measured at each level.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The two groups had similar heart rate, whereas acromegaly patients had higher body mass index, systolic and diastolic blood pressure, LV mass and impaired Doppler indexes of LV and RV diastolic function, without any difference in the global systolic function. At TD, acromegaly patients showed significantly delayed RT<jats:sub>m<\/jats:sub> and PCT<jats:sub>m,<\/jats:sub> reduced E<jats:sub>m<\/jats:sub>\/A<jats:sub>m<\/jats:sub>, S<jats:sub>m<\/jats:sub> and increased PCT<jats:sub>m<\/jats:sub>\/CT<jats:sub>m<\/jats:sub> of posterior septum, mitral annulus and tricuspid annulus in comparison with controls. By separate multilinear regression analyses, after adjusting for body mass index, heart rate, diastolic blood pressure and LV mass index, age was the main independent determinant of tissue Doppler diastolic but not of systolic indexes.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In active acromegaly, pulsed TD confirms LV and RV diastolic abnormalities detectable by standard Doppler, additionally identifying subclinical biventricular impairment of systolic function.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02475.x","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T09:04:56Z","timestamp":1140599096000},"page":"390-397","source":"Crossref","is-referenced-by-count":17,"title":["Pulsed tissue Doppler identifies subclinical myocardial biventricular dysfunction in active acromegaly"],"prefix":"10.1111","volume":"64","author":[{"given":"Maurizio","family":"Galderisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Pivonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreste de","family":"Divitiis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Colao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-1-11"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1987.tb00805.x"},{"key":"e_1_2_5_4_2","first-page":"1","article-title":"Mortality in acromegaly","volume":"39","author":"Wright A.D.","year":"1970","journal-title":"Quarterly Journal of Medicine"},{"key":"e_1_2_5_5_2","first-page":"327","article-title":"Epidemiology and long term survival in acromegaly","volume":"223","author":"Bengtsson B.","year":"1988","journal-title":"Acta Medica Scandinavica"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.4.1047"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.1.193"},{"key":"e_1_2_5_8_2","first-page":"41","article-title":"Acromegalic heart disease: influence of treatment of the acromegaly on the heart","volume":"62","author":"Hayward R.P.","year":"1987","journal-title":"Quarterly Journal of Medicine"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90083-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90477-7"},{"key":"e_1_2_5_11_2","first-page":"666","article-title":"Cardiac hypertrophy and function in asymptomatic patients with acromegaly","volume":"12","author":"Morvan D.","year":"1991","journal-title":"European Heart Journal"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.1.26"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(80)90277-X"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350308"},{"key":"e_1_2_5_15_2","first-page":"S33","article-title":"Is the growth hormone bad for your heart? 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