{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:28:51Z","timestamp":1773275331228,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,3,23]],"date-time":"2006-03-23T00:00:00Z","timestamp":1143072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the medium\u2010term outcome in a cohort of patients with residual or recurrent pituitary adenoma treated with fractionated stereotactic conformal radiotherapy (SCRT).<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> Ninety\u2010two patients (median age 50\u00a0years) with a residual or recurrent nonfunctioning (67) or a secreting (25) pituitary adenoma were treated between 1995 and 2003. Eighteen patients had a GH\u2010secreting, five PRL\u2010secreting and two an ACTH\u2010secreting pituitary adenoma. Vision was impaired in 39 patients, with visual field deficit (35) and\/or reduced visual acuity (25). Sixty\u2010four patients had partial or complete hypopituitarism before SCRT. The treatment was delivered stereotactically by four noncoplanar conformal fixed fields using a 6\u2010MV linear accelerator to a dose of 45 Gy in 25 fractions.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> At a median follow\u2010up of 32\u00a0months (range 4\u2013108) the 1, 3 and 5\u00a0years actuarial progression\u2010free survival is 99%, 98% and 98%, and overall survival is 98%. Three patients recurred 5\u00a0months, 1\u00a0year and 9\u00a0years after SCRT requiring surgery. In secreting adenomas, hormone levels declined progressively, becoming normal in more than a third of patients with GH\u2010secreting and PRL\u2010secreting pituitary tumours. 50% of baseline GH level was achieved in just under 2 years. The treatment was well tolerated with minimal acute toxicity. Hypopituitarism was the most common long\u2010term effect; 22% of patients had worsening of pituitary function. One patient developed unilateral quadrantopia without tumour progression.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> SCRT as a high\u2010precision technique of localized irradiation achieves tumour and hormone control of pituitary adenomas comparable with previously published data on the efficacy of conventional radiotherapy. Despite the potential advantage of reducing the volume of normal brain irradiated, the theoretical benefit over conventional radiotherapy in terms of the reduction in long\u2010term morbidity has not yet been demonstrated and requires longer follow\u2010up. Potential effect on long\u2010term cognitive function has not been tested.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02506.x","type":"journal-article","created":{"date-parts":[[2006,3,23]],"date-time":"2006-03-23T12:24:55Z","timestamp":1143116695000},"page":"542-548","source":"Crossref","is-referenced-by-count":114,"title":["Fractionated stereotactic conformal radiotherapy for secreting and nonsecreting pituitary 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