{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:59:02Z","timestamp":1761742742028},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,4,12]],"date-time":"2006-04-12T00:00:00Z","timestamp":1144800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Increased mortality due to cardiovascular disease has been described in adult patients with untreated GH deficiency (GHD). GH replacement has been demonstrate to improve vascular reactivity and reverse early atherosclerotic changes in adults with GHD.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> Assessment of fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function in hypopituitary adults with GHD at baseline and 1\u00a0year after GH replacement therapy.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We studied 10 patients with GHD (five men and five women; aged 45\u00b76\u00a0\u00b1\u00a010\u00b74\u00a0years) at baseline and 1\u00a0year after GH replacement therapy compared with a control group (nine men and 16 women) matched for age and body mass index (BMI). All subjects, patients and controls, were life\u2010long nonsmokers, normotensive and nondiabetic. The following variables were recorded: anthropometric and body composition variables, serum concentrations of glucose, insulin and C\u2010peptide; thrombin anti\u2010thrombin (TAT) fragments and fibrin degradation product D\u2010dimer, which were determined by an enzyme\u2010linked immunosorbent assay (ELISA); IGF\u2010I by radioimmunoassay (RIA); C\u2010reactive protein (CRP) by highly sensitive immunonephelometry; E\u2010selectin, P\u2010selectin, soluble intercellular cell adhesion molecule\u20101 (sICAM\u20101), soluble vascular cell adhesion molecule\u20101 (sVCAM\u20101), interleukin\u20106 (IL\u20106) and monocyte chemoattractant protein\u20101 (MCP\u20101) by ELISA. The assessment of endothelial function <jats:italic>in\u00a0vivo<\/jats:italic> was measured with a Doppler device.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Patients with GHD without GH substitution had higher hip\/waist ratio and body fat than controls. Insulin, C\u2010peptide and triglyceride concentrations were also higher. Our results demonstrated no difference in fibrinogen and in TAT fragment concentrations among patients and controls. E\u2010selectin concentrations were higher in patients than in controls (26\u00b71\u00a0\u00b1\u00a011 <jats:italic>vs<\/jats:italic>. 10\u00b77\u00a0\u00b1\u00a06\u00b72\u00a0\u00b5g\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70001). P\u2010selectin, sICAM\u20101, sVCAM\u20101, IL\u20106, MCP\u20101 and CRP were similar in the two groups. Vascular reactivity and carotid intima\u2013media thickness (IMT) were also similar in patients and controls. After 1\u00a0year of GH treatment we found no changes in biochemical parameters, fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Adults with GHD show some subtle changes in soluble adhesion molecules but our data suggest no beneficial effects of GH over these markers in relationship to endothelial function. Factors other than GH treatment, such as differences in age, degree of obesity, the presence of diabetes mellitus and arterial hypertension or tobacco consumption, could explain the observed increase in markers of vascular risk in GH\u2010deficient patients.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02518.x","type":"journal-article","created":{"date-parts":[[2006,4,23]],"date-time":"2006-04-23T15:44:11Z","timestamp":1145807051000},"page":"632-639","source":"Crossref","is-referenced-by-count":23,"title":["Peripheral fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function in hypopituitary adults with growth hormone deficiency"],"prefix":"10.1111","volume":"64","author":[{"given":"Jos\u00e9 Manuel","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Sah\u00fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Dom\u00e8nech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Catalina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Badim\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91812-O"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1169"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00695.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01797616"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.16.1.63"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-6374(03)00065-0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1300451"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb03937.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.1.153"},{"key":"e_1_2_6_13_2","first-page":"3","article-title":"Effect of 2 years of GH treatment on body composition and cardiovascular risk factors in adults with GH deficiency","volume":"4","author":"Johansson G.","year":"1996","journal-title":"Endocrinology and Metabolism"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.2.453"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02303.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02245.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01832.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.09.012"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01472.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93147-F"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_6_22_2","volume-title":"Fundamentals of Biostatistics","author":"Rossner B.","year":"1995"},{"key":"e_1_2_6_23_2","first-page":"70","volume-title":"Community Health Analysis. 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