{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T05:22:10Z","timestamp":1697260930754},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T00:00:00Z","timestamp":1147305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> GH and IGFBP\u20101 both play a role in glucose homeostasis.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the GH and IGFBP\u20101 responses to an oral glucose load and their relationship with glucose homeostasis in patients with primary hyperparathyroidism.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A cross\u2010sectional study with a control group followed by a longitudinal study after parathyroidectomy.<\/jats:p><jats:p><jats:bold>Patients and Methods\u2002<\/jats:bold> We studied 15 patients with primary hyperparathyroidism (eight women, aged 59\u00b76\u00a0\u00b1\u00a02\u00b72\u00a0years) and nine healthy normocalcaemic controls. All subjects were ambulatory and were studied as outpatients. Glucose, insulin, GH and IGFBP\u20101 were measured during an oral glucose (75\u00a0g) tolerance test (OGTT).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Patients with hyperparathyroidism showed similar glucose responses to OGTT to those found in controls. Insulin responses were higher in patients (peak insulin 96\u00b733\u00a0\u00b1\u00a09\u00b771\u00a0mU\/l) in relation to values found in controls (58\u00b711\u00a0\u00b1\u00a09\u00b703\u00a0mU\/l; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701). Suppression of GH levels after OGTT was more marked in patients [nadir 0\u00b703\u00a0(0\u00b702\u20130\u00b705)\u00a0\u00b5g\/l] than in normocalcaemic subjects [nadir GH 0\u00b712\u00a0(0\u00b708\u20130\u00b742)\u00a0\u00b5g\/l; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002]. However, baseline IGFBP\u20101 concentration and its decrease after glucose load were similar in patients and controls. Normalization of calcium levels after parathyroidectomy was not followed by any significant changes in glucose, insulin and GH responses to OGTT. The minimum concentration of IGFBP\u20101 and the area under the curve (AUC) of IGFBP\u20101 after OGTT were higher after parathyroidectomy (3\u00b734\u00a0\u00b1\u00a00\u00b769\u00a0\u00b5g\/l and 8\u00b794\u00a0\u00b1\u00a01\u00b772\u00a0\u00b5g.h\/l, respectively) than at diagnosis (2\u00b719\u00a0\u00b1\u00a00\u00b742\u00a0\u00b5g\/l and 6\u00b774\u00a0\u00b1\u00a01\u00b728\u00a0\u00b5g.h\/l, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). No correlation was found between PTH, calcium and phosphorus concentrations and GH and IGFBP\u20101 values in patients before or after normalization of calcium metabolism.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> GH and IGFBP\u20101 do not seem to be directly involved in the hyperparathyroidism\u2010associated changes in carbohydrate metabolism. The postoperative changes in the depression of IGFBP\u20101 after OGTT remain to be elucidated.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02541.x","type":"journal-article","created":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T15:46:38Z","timestamp":1147362398000},"page":"27-34","source":"Crossref","is-referenced-by-count":0,"title":["Growth hormone and insulin\u2010like growth factor binding protein\u20101 responses to oral glucose in patients with primary hyperparathyroidism"],"prefix":"10.1111","volume":"65","author":[{"given":"Juan 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