{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:03:30Z","timestamp":1791493410519,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,15]],"date-time":"2006-05-15T00:00:00Z","timestamp":1147651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background and objective\u2002<\/jats:bold> Previous studies on hypopituitarism and mortality have concluded that insufficient pituitary function is associated with decreased survival. For several reasons the results are difficult to compare \u2013 particularly because definitions and treatment of hypopituitarism have varied and various underlying disorders have been included. The purpose was to assess the relationship between mortality and pituitary function.<\/jats:p><jats:p><jats:bold>Patients and design\u2002<\/jats:bold> One hundred and sixty consecutive patients (99 men and 61 women) with functionless, suprasellar pituitary adenoma. All were operated on transsphenoidally during the period 1985\u20131996. Additional radiotherapy was given to 29 patients. Mortality was calculated 12\u00b74\u00a0years (median, range 8\u00b71\u201319\u00b79) after operation. Postoperative hormonal deficits were treated in most, though GH substitution was given only to a minority of patients.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Postoperatively 30% of the patients had normal pituitary function (normal adrenocortical, thyroid and gonadal function), 26% were panhypopituitary and 36% had partial pituitary insufficiency. Forty\u2010one patients had died (34\u00b77 expected) yielding a standard mortality ratio (SMR) of 1\u00b718 (95% confidence limits (CI) 0\u00b787\u20131\u00b760). SMR was significantly increased in women (1\u00b797, CI 1\u00b720\u20133\u00b721) but not in men (0\u00b783, CI 0\u00b755\u20131\u00b726). SMR in patients with normal pituitary function, panhypopituitarism and partial insufficiency were not different from that in the general population. SMR in hypopituitary women was substantially higher than in men with pituitary insufficiency. Treatment with growth hormone in GH\u2010deficient patients did not influence survival.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Pituitary surgery for nonfunctioning adenoma and subsequent pituitary insufficiency had no effect on mortality in men, but was associated with significantly increased mortality in women. Suboptimal hormonal substitution in women may play a role.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02545.x","type":"journal-article","created":{"date-parts":[[2006,5,15]],"date-time":"2006-05-15T13:07:37Z","timestamp":1147698457000},"page":"51-58","source":"Crossref","is-referenced-by-count":56,"title":["Hypopituitarism and mortality in pituitary adenoma"],"prefix":"10.1111","volume":"65","author":[{"given":"J.","family":"Lindholm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Husted","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bjerre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Sandahl","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Juul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Laurberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Stochholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01681114"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1190185"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1145197"},{"key":"e_1_2_5_5_2","first-page":"621","article-title":"Erfolgreiche Operation eines Hypophysentumours auf nasalem Wege","volume":"20","author":"Schloffer H.","year":"1907","journal-title":"Wiener Medizinische Wochenschrift"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009927312197"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91812-O"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1169"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00650.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02463.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1467"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/jcem.87.2.8216","article-title":"Which patients do not require a GH stimulation test for the diagnosis of adult GH deficiency?","volume":"87","author":"Hartman M.L.","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01159.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-2-505"},{"key":"e_1_2_5_17_2","volume-title":"Statistical Methods in Medical Research","author":"Armitage P.","year":"1987"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90373-1"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90090-6"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01163.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.2.473"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1420"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01570.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030461"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.79.6.709"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(97)00207-X"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.3.357"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90353-5"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02928.x"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.8.2664"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021558"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.1.117"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02035.x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2006.02545.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2006.02545.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:48:23Z","timestamp":1697233703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2006.02545.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,25]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1365-2265.2006.02545.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02545.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,25]]}}}