{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:52:43Z","timestamp":1770432763671,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate the sleep architecture and breathing as well as quality of life (QoL) in adults with GH deficiency (GHD) before and 6\u00a0months after GH replacement therapy.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A prospective observational study.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Nineteen consecutive adults with GHD (11 men, eight women; mean age 53, range 21\u201373\u00a0years) were studied.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> An overnight sleep study was performed and the Minor Symptom Evaluation Profile (MSEP), Functional Outcome of Sleep Questionnaire (FOSQ), Short Form 36 (SF\u201036) and Epworth Sleepiness Scale (ESS) questionnaires were applied at baseline and after the treatment period.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> For the whole group, there were no significant changes in mean total sleep time (TST; 370\u00a0min <jats:italic>vs.<\/jats:italic> 374\u00a0min), proportion of slow\u2010wave sleep (SWS; 17\u00b78%<jats:italic>vs.<\/jats:italic> 18\u00b74%) and rapid eye movement (REM) sleep (12\u00b71%<jats:italic>vs.<\/jats:italic> 13\u00b79%) on GH replacement. Mean apnoea\u2013hypopnoea index (AHI) was high and remained unchanged (28\u00b72\/h before <jats:italic>vs.<\/jats:italic> 28\u00b70\/h following GH replacement). Twelve patients (63%) were found to have obstructive sleep apnoea (OSA; AHI\u00a0\u2265\u00a010\/h) at baseline. Compared with GH\u2010deficient patients without OSA (AHI 3\u00b79\/h), the OSA patients (AHI 42\u00b74\/h) had less SWS (11\u00b74%<jats:italic>vs.<\/jats:italic> 28\u00b76%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7010) and REM sleep (10\u00b71%<jats:italic>vs.<\/jats:italic> 15\u00b75%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7036). A marginal increase was observed in REM sleep time (10\u00b71% before <jats:italic>vs.<\/jats:italic> 12\u00b77% after GH; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7048) while SWS was unchanged in this group. Moreover, MSEP for General Well\u2010being and Responsiveness, FOSQ scores for General Productivity, Activity Level and Vigilance as well as SF\u201036 domains for Vitality and Mental Health were improved.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Contrary to some previous observations in a smaller group of patients, our data suggest that GH therapy does not induce or aggravate OSA in GH\u2010deficient adults. Moreover, GH therapy may improve some of the QoL dimensions in these patients.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02555.x","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T22:34:42Z","timestamp":1149201282000},"page":"98-105","source":"Crossref","is-referenced-by-count":29,"title":["Sleep apnoea and quality of life in growth hormone (GH)\u2010deficient adults before and after 6\u00a0months of GH replacement 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