{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:07:38Z","timestamp":1768414058783,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant syndrome characterized by primary hyperparathyroidism, pituitary neoplasia and foregut lineage neuroendocrine tumours. It has also been associated with premature cardiovascular death. As diabetes is a risk factor for increased cardiovascular mortality we investigated the prevalence and clinical correlates of glycaemic abnormalities in a large MEN 1 kindred.<\/jats:p><jats:p><jats:bold>Patients and design\u2002<\/jats:bold> The glycaemic status of 72 MEN 1 affected and 133 unaffected members of a single large MEN 1 pedigree was assessed. Fasting glucose results were categorized and compared using WHO criteria. Associations between glycaemic status and MEN 1 phenotype were assessed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Thirteen (18\u00b71%) patients with MEN 1 compared to 5 (3\u00b78%) control patients were diabetic (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001). Six (8\u00b73%) MEN 1 patients had impaired fasting glucose compared to 4 (3%) of controls (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b705). Of patients with MEN 1, uncontrolled hypercalcaemia (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b705) and elevated serum gastrin (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b705) were more common amongst patients diagnosed with abnormal glycaemia than those with normoglycaemia. There was a nonsignificant trend for elevated chromogranin A, pancreatic polypeptide, gastric inhibitory polypeptide (but not glucagon) and history of bronchopulmonary carcinoid in MEN 1 patients with elevated glycaemia.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Diabetes and impaired fasting glucose occur significantly more frequently amongst MEN 1 patients than controls and is associated with uncontrolled hyperparathyroidism and evidence of enteropancreatic hyperstimulation.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02563.x","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T22:34:42Z","timestamp":1149201282000},"page":"163-168","source":"Crossref","is-referenced-by-count":29,"title":["Multiple endocrine neoplasia type 1 (MEN 1) is associated with an increased prevalence of diabetes mellitus and impaired fasting glucose"],"prefix":"10.1111","volume":"65","author":[{"given":"Roland W.","family":"McCallum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkat","family":"Parameswaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-6-199809150-00011"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-8529(18)30112-9","article-title":"Multiple endocrine neoplasia type 1: clinical features and screening","volume":"1","author":"Skogseid B.","year":"1994","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.2000.0150"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490577"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900438"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1993.01420180085016"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010237"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.05.044"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2005.09.008"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-7-199804010-00002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","unstructured":"Burnett M.S. 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