{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:42:57Z","timestamp":1790811777906,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T00:00:00Z","timestamp":1157414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The aim of the study was to characterize lipid oxidation at exercise in adults with growth hormone deficiency (GHD) and to evaluate the effect of 6 and 12\u00a0months of GH replacement therapy on substrate carbohydrate (CHO) and lipid utilization at exercise.<\/jats:p><jats:p><jats:bold>Patients and measurements\u2002<\/jats:bold> Twenty\u2010five patients with GHD and 40 matched controls participated in the study. Ten of the 25 GH\u2010deficient patients were treated with recombinant GH for 12\u00a0months. Anthropometric measurements and exercise calorimetry were performed before and after treatment. Maximal fat oxidation and the crossover point [that is the percentage of the theoretical maximal power (Wmax\u00a0th) where CHO become the predominant fuel used for oxidation] were determined.<\/jats:p><jats:p><jats:bold>Results and conclusion\u2002<\/jats:bold> The GH\u2010deficient patients exhibited a highly significant shift in the balance of substrate oxidation during exercise, towards a decrease in fat oxidation, and a shift towards lower intensities of the crossover (52\u00a0\u00b1\u00a05\u00b75%<jats:italic>vs.<\/jats:italic> 72\u00b76\u00a0\u00b1\u00a06\u00b76% of Wmax\u00a0th, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b703) and maximal fat oxidation (131\u00b704\u00a0\u00b1\u00a014 <jats:italic>vs.<\/jats:italic> 234\u00b74\u00a0\u00b1\u00a030\u00b71\u00a0mg\/min, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b703) in the GHD and control groups, respectively. However, GH treatment at 6 and 12 months partially reversed this defect, resulting in an increase (+83%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) in the maximal ability to oxidize fat during exercise. These findings are consistent with the hypothesis that a lack of GH reduces the ability to oxidize lipids during exercise and that GH treatment restores this muscular metabolic property.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02578.x","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T15:08:52Z","timestamp":1157468932000},"page":"423-428","source":"Crossref","is-referenced-by-count":14,"title":["Lower ability to oxidize lipids in adult patients with growth hormone (GH) deficiency: reversal under GH treatment"],"prefix":"10.1111","volume":"65","author":[{"given":"F.","family":"Brandou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Aloulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Razimbaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"F\u00e9dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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