{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:26:31Z","timestamp":1774686391347,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T00:00:00Z","timestamp":1152144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Among the parathyroid imaging techniques, ultrasonography (USG) has the advantage of convenience, easy availability and low cost.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To study the role of USG in localization (side and\/or site) of abnormal parathyroid glands in primary hyperparathyroidism (PHPT) and to compare with radionuclide scintigraphy and the \u2018gold standard\u2019, surgery.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Forty\u2010six consecutive patients undergoing USG of the anterior neck for a diagnosis of PHPT in whom a nuclear scan (technetium\u201099m sestamibi and\/or thallium\u2010201\/technetium\u201099m pertechnetate scintigraphy) was also performed, were studied. The results of imaging were independently interpreted and correlated with reference to surgical findings.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Forty\u2010six patients had 52 abnormal parathyroid glands on surgical exploration and surgery was successful in all but one. Forty\u2010one patients had a single adenoma, four had multigland disease and one had a paraganglioma. USG correctly localized the abnormal gland in 30 (73%) and scintigraphy was positive in 40 (98%) out of 41 patients with a single adenoma as confirmed on surgical exploration. Scintigraphy showed a positive concordant test in all 30 patients with a single abnormal gland detected on USG and picked up 10 out of 11 abnormal glands where USG was negative. The sensitivity and positive predictive value of USG for detecting a single abnormal gland was 73% and 100%, respectively, whereas the sensitivity and positive predictive value for scintigraphy was 98%. In patients with multigland disease, USG missed 3 (30%) out of 10 and scintigraphy missed 6 (60%) out of 10 abnormal parathyroid glands as confirmed on surgical exploration (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b705). However, in two patients who had ectopic parathyroid gland, both the modalities localized the lesion in one (paraganglioma), whereas in the other neither test was helpful (left retro\u2010esophageal).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> USG is a convenient, affordable and useful modality to localize abnormal enlarged parathyroid glands in the majority of patients with PHPT. However, when USG is negative, scintigraphy is complementary to it.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02601.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T13:07:04Z","timestamp":1152277624000},"page":"340-345","source":"Crossref","is-referenced-by-count":56,"title":["Ultrasonography in detection of single and multiple abnormal parathyroid glands in primary hyperparathyroidism: comparison with radionuclide scintigraphy and surgery"],"prefix":"10.1111","volume":"65","author":[{"given":"A.","family":"Bhansali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Masoodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bhadada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. R.","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Behra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1975.01360110171028"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(87)80026-0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7708-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200205000-00008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900127"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2099.101834"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3944(01)00520-X"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(85)80024-6"},{"key":"e_1_2_5_10_2","first-page":"553","volume-title":"The Parathyroids","author":"Doppman J.L.","year":"1994"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197909063011007"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.161.1.3020610"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80304-0"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(89)90703-0"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.166.6.8633466"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-198911000-00003"},{"key":"e_1_2_5_17_2","first-page":"1801","article-title":"Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with technetium\u201099m\u2010sestamibi (double\u2010phase study)","volume":"33","author":"Taillefer R.","year":"1992","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182301"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.1.302"},{"key":"e_1_2_5_20_2","first-page":"27","article-title":"Single radionuclide scintigraphy with 99mtechnetium\u2010sestamibi and ultrasonography in hyperparathyroidism","volume":"163","author":"Bonjer H.J.","year":"1997","journal-title":"European Journal of Surgery"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02439546"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2099.101579"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.107066"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80335-6"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.1.346"},{"key":"e_1_2_5_26_2","first-page":"562","article-title":"Prospective comparison of dual\u2010phase technetium\u201099m\u2010sestamibi scintigraphy and high resolution ultrasonography in the evaluation of abnormal parathyroid glands","volume":"62","author":"Light V.L.","year":"1996","journal-title":"American Surgeon"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01775.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2005.29"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02043.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.02.008"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.2.r00fe04393"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)81656-3"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067321"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841859609177706"},{"key":"e_1_2_5_35_2","first-page":"313","article-title":"Parathyroid imaging with technetium\u201099m sestamibi preoperative localization and tissue uptake studies","volume":"33","author":"O'Doherty M.J.","year":"1992","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.10.021"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2005.06.001"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2006.02601.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2006.02601.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:53:49Z","timestamp":1697237629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2006.02601.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,6]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-2265.2006.02601.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02601.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,6]]}}}