{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:54Z","timestamp":1783486254508,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T00:00:00Z","timestamp":1152489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> It has been reported that hypothyroidism is associated with better survival in elderly persons. We investigated possible associations of thyroid status with clinical outcome in patients with acute stroke.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Retrospective analysis.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Consecutive patients (median age 70\u00a0years) admitted for acute stroke.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Total T3, T4 and TSH levels. Stroke severity evaluation using the Scandinavian Stroke Scale (SSS) and the Glasgow Coma Score (GCS). Handicap and survival assessment over 12\u00a0months.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Of 744 patients where thyroid function tests were available within the first 24\u00a0h of stroke, 13 had elevated TSH (\u2265\u00a010\u00a0\u00b5U\/ml; range 10\u201342\u00a0\u00b5U\/ml) (hypo\u2010group), 51 had mildly elevated TSH (3\u00b73\u20139\u00b79\u00a0\u00b5U\/ml) and 680 had nonelevated TSH\u00a0&lt;\u00a03\u00b73\u00a0\u00b5U\/ml. In the hypo\u2010group transient ischaemic attacks (TIA's) were more prevalent (46\u00b72%) compared to the groups of mildly elevated TSH (11\u00b78%) and nonelevated TSH (12\u00b74%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7002). Hypo\u2010group had more frequently an adequate level of consciousness (GCS 14\u201315\u00a0=\u00a0fully alert): 92\u00b73%<jats:italic>vs<\/jats:italic> 74\u00b75% and 63\u00b77% (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7033), a milder neurological deficit (SSS score 45\u201358) 76\u00b79%<jats:italic>vs<\/jats:italic> 39\u00b72% and 38\u00b77% (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b702) compared to the other two groups, respectively, and a tendency for lower glucose levels on admission. One year outcome tended to be better with respect to survival and handicap.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Acute stroke patients with laboratory findings compatible with pre\u2010existing hypothyroidism on admission, appear to have better clinical presentation and outcome; we speculate that a reduced response to stress and previous TIA's, possibly related to endogenous \u2018preconditioning\u2019, may contribute to this phenomenon.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02606.x","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T18:00:29Z","timestamp":1152554429000},"page":"369-372","source":"Crossref","is-referenced-by-count":37,"title":["Hypothyroidism as a protective factor in acute stroke patients"],"prefix":"10.1111","volume":"65","author":[{"given":"Maria","family":"Alevizaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Synetou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Xynos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calliope C.","family":"Alevizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas 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