{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:15:39Z","timestamp":1697271339315},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> IGFs and IGF binding proteins in the circulation are subject to modulation by a number of catabolic states including inflammation, trauma and surgery. We sought to determine the impact of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> The components of the IGF system, cortisol, glucose and insulin concentration in both the serum and urine of patients were compared to those from a healthy group of subjects. An additional comparison was made between pre\u2010 and post\u2010laparoscopically assisted patients.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Thirty patients diagnosed with acute cholecystitis and 81 matched controls were included in the study.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Radioimmunoassays were used to determine the IGF\u2010I, IGF\u2010II, insulin and cortisol concentrations. The concentration of IGFBP\u20103 was measured using an immunoradiometric assay. The GOD\u2010PAP method was used to determine the glucose concentration. Gel filtration chromatography was performed to calculate the IGF binary\/ternary complex ratio. The amount of sialic acid in IGFBP\u20103 was determined by affinity chromatography. The presence of IGFBPs in serum was determined by both immunoblotting and ligandblotting.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The concentrations of circulating IGF\u2010I, IGF\u2010II and IGFBP\u20103 were significantly reduced in pre\u2010operative patients compared to healthy subjects. No further reductions were observed post\u2010laparoscopy. Immunoblotting and ligandblotting demonstrated a decreased amount of IGFBP\u20103 in both pre\u2010 and post\u2010operative patients compared to healthy subjects. Increased levels of IGFBP\u20102 and IGFBP\u20101 were observed in pre\u2010operative patients compared to healthy subjects, but laparoscopy did not cause further elevation. No alteration in the IGF binary\/ternary complex ratio was witnessed between any of the study groups. A significant increase in the sialic acid content of IGFBP\u20103 was seen in both patient groups when compared to healthy subjects. The level of urinary cortisol was significantly increased in post\u2010operative patients, whereas the urinary IGF\u2010I concentration was decreased compared to healthy subjects.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our results indicate that acute cholecystitis causes several significant changes in the circulating IGF system. Laparoscopy, however, does not aggravate such changes, but elevates urinary cortisol.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02607.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T09:35:11Z","timestamp":1152696911000},"page":"373-379","source":"Crossref","is-referenced-by-count":3,"title":["The effect of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis"],"prefix":"10.1111","volume":"65","author":[{"given":"Ivona","family":"Baricevi\u00e7","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Malenkovi\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olgica","family":"Nedi\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(03)00005-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/EDR.2003.205"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0033"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.6.1631"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1320433"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1440109"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/beem.2001.0161"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/beem.2001.0162"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2004.09.005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-004-8906-x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0512-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.04.020"},{"key":"e_1_2_6_14_2","first-page":"1149","article-title":"Determination of insulin\u2010like growth factor\u2010I by radioimmunoassay","volume":"61","author":"Nikolic J.A.","year":"1996","journal-title":"Journal of Serbian Chemical Society"},{"key":"e_1_2_6_15_2","first-page":"805","article-title":"Determination of insulin\u2010like growth factor\u2010II in human serum","volume":"63","author":"Nikolic J.A.","year":"1998","journal-title":"Journal of Serbian Chemical Society"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2005.05.034"},{"key":"e_1_2_6_17_2","first-page":"138","article-title":"Analysis of serum insulin\u2010like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins and competitive binding studies","volume":"154","author":"Hossenlopp P.","year":"1986","journal-title":"Analytical Chemistry"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-924972"},{"key":"e_1_2_6_19_2","first-page":"645","article-title":"Part 5. 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