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Because survival rates have improved markedly, the long\u2010term complications, such as GH deficiency (GHD) and neuropsychological impairment, have become increasingly important.<\/jats:p><jats:p><jats:bold>Design and patients\u2002<\/jats:bold> The level of self\u2010reported quality of life and neuropsychological functioning was investigated in 44 adults (21 women) with a median age of 25\u00a0years who had been treated for childhood onset (CO) ALL with CRT (median 24\u00a0Gy). Comparison was made with matched population controls. A subset of patients with GHD was evaluated for neuropsychological functioning after 1\u00a0year of GH treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Compared to controls, the patients had significantly lower performance in neuropsychological tests. Early age at treatment had a significant negative impact on neuropsychological performance in adulthood. No relationship was found between dose of CRT, time since treatment of ALL or gender and neuropsychological performance. Compared to controls, the patients did not show a poor quality of life or a lowered availability of social interactions or social networks; however, significantly more patients were living alone or with their parents. After GH testing, the patients were all considered GH deficient or insufficient, but no relationship was observed between stimulated peak GH secretion and neuropsychological performance. Treatment with GH for 1\u00a0year in a subgroup of the patients did not improve their neuropsychological performance.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This study showed that adults treated with CRT for CO\u00a0ALL had GHD and significantly impaired neuropsychological performance, although self\u2010reported quality of life was not affected. The effect of GH treatment in this patient group has to be further elucidated.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02637.x","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T20:11:33Z","timestamp":1157746293000},"page":"617-625","source":"Crossref","is-referenced-by-count":23,"title":["Adult survivors of childhood acute lymphoblastic leukaemia with GH deficiency have normal self\u2010rated quality of life but impaired neuropsychological performance 20\u00a0years after cranial 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