{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:58:02Z","timestamp":1761512282360},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T00:00:00Z","timestamp":1155081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> GH dose requirement is lower in ACTH replete compared with ACTH deficient hypopituitary patients suggesting that adrenal androgens may augment IGF\u2010I generation for a given GH dose. This study aimed to determine the effect of dehydroepiandrosterone (DHEA) administration on GH dose requirements in hypopituitary adults.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A double blind placebo controlled trial was conducted adding 50\u00a0mg DHEA to the standard replacement of hypopituitary patients, including GH, over an initial 6\u00a0months, followed by an open phase study of 6\u00a0months DHEA replacement and a final 2\u00a0month washout phase after DHEA withdrawal. The dose of GH was adjusted to achieve a constant serum IGF\u2010I.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Thirty female and 21 male hypopituitary patients were enrolled. Data from 26 women and 18 men were analysed after patient withdrawal.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> The primary outcome objective was the GH dose required to achieve a stable serum IGF\u2010I. Secondary outcome measures were lipoprotein profiles, insulin, insulin sensitivity, IGFBP\u20103, waist\/hip ratio and indices of bone remodelling.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> DHEA replacement in female patients lead to a 14\u00b76\u00a0\u00b1\u00a020% reduction in the dose of GH for a constant serum IGF\u2010I (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b705, 95% CI: 1\u00b78, 32\u00b77). This was maintained for 12\u00a0months and there was a significant fall in serum IGF\u2010I two months after withdrawal of DHEA. There was no change in the male group.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> DHEA replacement may reduce GH dose requirements in female hypopituitary patients.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02648.x","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T14:10:01Z","timestamp":1155132601000},"page":"673-680","source":"Crossref","is-referenced-by-count":22,"title":["Dehydroepiandrosterone (DHEA) replacement reduces growth hormone (GH) dose requirement in female hypopituitary patients on GH replacement"],"prefix":"10.1111","volume":"65","author":[{"given":"Antonia M.","family":"Brooke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonila A.","family":"Kalingag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farideh","family":"Miraki\u2010Moud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Camacho\u2010H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine T.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy M.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy P.","family":"Hinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Monson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb01830.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00364.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.11.4172"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1727"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.7.2989"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01759.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.3.1121"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1210\/jcem.83.6.4850","article-title":"Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and oestrogens in young females after dexamethasone suppression","volume":"83","author":"Arlt W.","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01017.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.12.4650"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909303411401"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020769"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.2046"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1802"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.8.2578"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.6.1360"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0020201"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/clinchem\/22.10.1627","article-title":"Cholesterol oxidase based determination by continuous\u2010flow analysis of total and free cholesterol in serum","volume":"22","author":"Lie R.","year":"1976","journal-title":"Clinical Chemistry"},{"key":"e_1_2_6_21_2","first-page":"882","article-title":"Cholesterol oxidase based determination by continuous\u2010flow analysis of total and free cholesterol in serum","volume":"23","author":"Lopez\u2010Virella M.","year":"1977","journal-title":"Clinical Chemistry"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/clinchem\/28.10.2077","article-title":"Serum triglycerides determined calorimetrically with an enzyme that produces hydrogen peroxide","volume":"28","author":"Fossati P.","year":"1982","journal-title":"Clinical Chemistry"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative centrifuge","volume":"18","author":"Friedewald W.","year":"1972","journal-title":"Clinical Chemistry"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1210\/jcem.83.11.5223","article-title":"Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults","volume":"83","author":"Drake W.M.","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.3.765"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.5.1968"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01810"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450457"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021603"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00507.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-1-57"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-3-696"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2006.02648.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2006.02648.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:13:04Z","timestamp":1697238784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2006.02648.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1365-2265.2006.02648.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02648.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,9]]}}}