{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:14:29Z","timestamp":1767374069499},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To describe the effect of T4 replacement in patients with primary and central hypothyroidism on components of the IGF binding protein complex: IGF\u2010I, the acid\u2010labile subunit (ALS) and IGFBP\u20103.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> We determined IGF\u2010I, ALS and IGFBP\u20103 (by <jats:sup>125<\/jats:sup>I\u2010IGF\u2010II ligand blots and immunoblots) in serum of 19 patients with primary and 11 patients with central hypothyroidism.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Mean\u00a0(\u00b1\u00a0SD) free T4 (fT4) increased from 4\u00b74\u00a0\u00b1\u00a02\u00b74\u00a0pmol\/l at baseline to 18\u00b76\u00a0\u00b1\u00a05\u00b72\u00a0pmol\/l following T4 therapy. In patients with primary hypothyroidism, IGF\u2010I concentrations increased from 101\u00a0\u00b1\u00a057 to 158\u00a0\u00b1\u00a060\u00a0\u00b5g\/l (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and ALS from 12\u00b76\u00a0\u00b1\u00a04\u00b77 to 15\u00b76\u00a0\u00b1\u00a05\u00b72\u00a0mg\/l (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001). IGFBP\u20103 levels (in arbitrary units, AU), assessed by <jats:sup>125<\/jats:sup>I\u2010IGF\u2010II ligand blot and by Western blot (the intensity of the 45\/42\u2010kDa doublet following T4 replacement defined as 1\u00a0AU) increased from 0\u00b774\u00a0\u00b1\u00a00\u00b747 to 1 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7029) and from 0\u00b776\u00a0\u00b1\u00a00\u00b742 to 1 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7018), respectively. In patients with hypopituitarism, IGF\u2010I and ALS concentrations increased on T4 therapy from 49\u00a0\u00b1\u00a023 to 97\u00a0\u00b1\u00a036\u00a0\u00b5g\/l (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and from 7\u00b78\u00a0\u00b1\u00a04\u00b71 to 11\u00b70\u00a0\u00b1\u00a02\u00b77\u00a0mg\/l (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7010), respectively. IGFBP\u20103 remained unchanged during T4 replacement.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> T4 replacement increases the serum levels of IGF\u2010I and ALS in patients with primary as well as central hypothyroidism. IGFBP\u20103 levels increase in response to T4 replacement in patients with primary hypothyroidism but not in those with central hypothyroidism, suggesting that thyroid hormones increase IGF\u2010I and ALS but not IGFBP\u20103 in patients with GH deficiency.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02652.x","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T11:22:55Z","timestamp":1156504975000},"page":"706-711","source":"Crossref","is-referenced-by-count":23,"title":["Effect of thyroxine replacement on serum IGF\u2010I, IGFBP\u20103 and the acid\u2010labile subunit in patients with hypothyroidism and 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