{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:07:06Z","timestamp":1770062826208,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:00:00Z","timestamp":1163635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Primary hyperparathyroidism (PHPT) is associated with heart disease. The aims of the present study were to evaluate how cardiac function and secretion of N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP) correlate in patients with mild PHPT, and how the plasma level of NT\u2010proBNP is influenced by cure of the parathyroid disease.<\/jats:p><jats:p><jats:bold>Design and patients\u2002<\/jats:bold> Forty\u2010two patients with PHPT without symptoms of heart disease were examined before and 1\u00a0year after curative parathyroidectomy.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Plasma or serum concentrations of NT\u2010proBNP, calcium, PTH, creatinine, oestradiol, testosterone and SHBG were measured. Cardiac function was evaluated by equilibrium radionuclide angiography (ERNA).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> At baseline, NT\u2010proBNP levels correlated negatively with systolic function [left ventricular ejection fraction (LVEF), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001]. Twelve per cent of the patients had NT\u2010proBNP levels above normal reference values preoperatively. One year postoperatively, the corresponding proportion was 21%. The mean plasma concentration of NT\u2010proBNP increased after parathyroidectomy (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b701) in parallel with a dip in diastolic function (peak filling rate, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) and a falling trend in systolic function (LVEF, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b708). The postoperative percentage changes in circulating NT\u2010proBNP and total oestradiol correlated positively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Patients with mild PHPT and normal renal function may have high levels of circulating NT\u2010proBNP despite the absence of symptomatic heart disease. Cure of the parathyroid disease is followed by a further increase in NT\u2010proBNP secretion in parallel with ERNA measures, indicating subclinical changes in heart function. These results are in line with data indicating an association between PHPT and increased risk of premature death.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02663.x","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T09:00:06Z","timestamp":1163667606000},"page":"760-766","source":"Crossref","is-referenced-by-count":8,"title":["Increased plasma concentrations of N\u2010terminal pro\u2010B\u2010type natriuretic peptide in patients with mild primary hyperparathyroidism"],"prefix":"10.1111","volume":"65","author":[{"given":"Erik G.","family":"Almqvist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Greth","family":"Bondeson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Bondeson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven\u2010Eric","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,16]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"13","article-title":"Causes of death in patients previously operated on for primary hyperparathyroidism","volume":"74","author":"Ronni\u2010Sivula H.","year":"1985","journal-title":"Annales Chirurgiae et Gynaecologiae"},{"key":"e_1_2_6_3_2","first-page":"1","article-title":"Mortality after surgery for primary hyperparathyroidism: a follow\u2010up of 441 patients operated on from 1956 to 1979","volume":"102","author":"Palm\u00e9r M.","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01670531"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.07.010"},{"key":"e_1_2_6_6_2","first-page":"H1998","article-title":"Parathyroid hormone increases cytosolic calcium concentration in adult rat cardiac myocytes","volume":"264","author":"Smogorzewski M.","year":"1993","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-7-593"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021370"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128692"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-5-345"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2002.24599"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.024760"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.06.009"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2003.00484.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1916.00080130010002"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030736"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456329503200401"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.1929"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.07.010"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.3.264"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.1.21"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01525-5"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.026021"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.01941.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00478-1"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01594.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2005.08.011"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1042\/cs1010447","article-title":"Increase in circulating levels of cardiac natriuretic peptides after hormone replacement therapy in postmenopausal women","volume":"101","author":"Maffei S.","year":"2001","journal-title":"Clinical Science"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02416.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000125451.28861.2a"},{"key":"e_1_2_6_34_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1210\/jcem.82.1.3666","article-title":"Cardiac abnormalities in patients with primary hyperparathyroidism: implications for follow\u2010up","volume":"82","author":"Stefenelli T.","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00651.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02059-4"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.10.1252"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02363.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.157"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.110240"},{"key":"e_1_2_6_41_2","first-page":"171","article-title":"Cardiac output in asymptomatic primary hyperparathyroidism: a stigma of early cardiovascular dysfunction","volume":"81","author":"Georgiannos S.N.","year":"1996","journal-title":"International Surgery"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-4-524"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.7.3024"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2006.02663.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2006.02663.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:21:44Z","timestamp":1697235704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2006.02663.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,16]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2265.2006.02663.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02663.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,16]]}}}