{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:30:23Z","timestamp":1783485023666,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Few studies using ultrasonographic evaluation have addressed the natural course of benign thyroid nodules. In this study, we present the long\u2010term analysis of benign, untreated thyroid nodules in a moderately iodine\u2010deficient area.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> We collected the retrospective data for 531 nodules in 420 patients followed by ultrasonography for a mean time period of 39\u00b77\u00a0\u00b1\u00a027\u00b78\u00a0months (range 12\u2013168\u00a0months).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> When we considered significant nodule size decrease criteria as decreases in nodule volume of at least 15% and 30%, we found that 33\u00b71% and 20\u00b77% of thyroid nodules decreased in size, respectively. Using the criteria of a greater than 15% and 30% increase in volume showed that 32% and 24\u00b71% increased in size, respectively. A logistic regression analysis using mixed models to predict thyroid nodule growth (volume change \u2265\u00a015%), including age, TSH, sex and time between evaluations, failed to predict nodule growth. Only hypoechoic echo pattern remained as a statistically significant predictor of growth.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> In 40\u00a0months\u2019 follow\u2010up, we found that benign thyroid nodules exhibited a mostly favourable clinical natural course. One\u2010third of benign thyroid nodules showed continuous growth, one\u2010third remained unchanged, and the other third decreased in size.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02664.x","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T11:22:55Z","timestamp":1156504975000},"page":"767-771","source":"Crossref","is-referenced-by-count":39,"title":["Natural course of benign thyroid nodules in a moderately iodine\u2010deficient area"],"prefix":"10.1111","volume":"65","author":[{"given":"Murat Faik","family":"Erdogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alptekin","family":"Gursoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurbuz","family":"Erdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302253280807"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-69-3-537"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1977.tb01340.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-15-10-1270"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0016"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.3.1947082"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-001-1163-7"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.2.600"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1070506"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.1069"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00353745"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1420224"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.215.3.r00jn07801"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343926"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34992"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1210\/jcem.83.3.4615","article-title":"Long\u2010term changes in nodular goiter: a 5\u2010year prospective randomized trial of levothyroxine suppressive therapy for benign cold thyroid nodules","volume":"83","author":"Papini E.","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658447"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-4-200302180-00010"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010959928862"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343994"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1996.15.12.813"},{"key":"e_1_2_5_23_2","first-page":"1057","article-title":"Sonographic presentation in autoimmune thyroiditis","volume":"89","author":"Lai S.M.","year":"1990","journal-title":"Journal of the Formosan Medical Association"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.2307\/2685737"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531734"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2006.02664.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2006.02664.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:21:46Z","timestamp":1697235706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2006.02664.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,20]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2265.2006.02664.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02664.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,20]]}}}