{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:51:19Z","timestamp":1791345079382,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:00:00Z","timestamp":1163635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine whether maternal serum leptin levels can predict pregnancy outcome in cases of threatened miscarriage.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Observational study.<\/jats:p><jats:p><jats:bold>Patients<\/jats:bold> \u2002Fifty\u2010seven women with normal pregnancy (group\u00a0A), 19 women with threatened miscarriage who delivered at term (group\u00a0B), 22 women with threatened miscarriage with subsequent miscarriage (group\u00a0C) and 27 women with delayed miscarriage (group\u00a0D).<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Maternal serum leptin was determined using a commercial radioimmunoassay (RIA) kit.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Serum leptin levels were not significantly different among groups\u00a0A, B and C [median\u00a0(range) 17\u00b76\u00a0(10\u00b71\u201326\u00b75), 18\u00b72\u00a0(12\u00b75\u201325\u00b76) and 17\u00b73\u00a0(11\u00b72\u201327\u00b76)\u00a0\u00b5g\/l, respectively]. Women in group\u00a0D showed significantly lower serum leptin levels in comparison with other groups [14\u00a0(6\u00b77\u201321\u00b73)\u00a0\u00b5g\/l; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705].<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Serum leptin levels in the first trimester of pregnancy may not be the primary indicator of miscarriage in cases of threatened abortion.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02665.x","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T09:00:06Z","timestamp":1163667606000},"page":"772-775","source":"Crossref","is-referenced-by-count":12,"title":["Do serum leptin levels have a role in the prediction of pregnancy outcome in case of threatened miscarriage?"],"prefix":"10.1111","volume":"65","author":[{"given":"Giovanni A.","family":"Tommaselli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Di Spiezio Sardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Di Carlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bifulco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cerrota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Nappi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.7.8770941"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0396-318"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.7.855"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1210\/jcem.82.5.3935","article-title":"Levels of leptin in maternal serum amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight","volume":"82","author":"Schubring C.","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200011000-00016"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.5.847"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00668-9"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.9.3225"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590400007267"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00637.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.9.2008"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod60.2.216"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/gye.16.6.479.491","article-title":"Effects of sex steroids hormones and menopause on serum leptin levels","volume":"16","author":"Di Carlo C.","year":"2003","journal-title":"Gynecological Endocrinology"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:16:1:21"},{"key":"e_1_2_5_18_2","first-page":"65","article-title":"Mechanisms of endometrial control of trophoblast invasion","volume":"55","author":"Bischof P.","year":"2000","journal-title":"Journal of Reproduction and Fertility. 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