{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:51Z","timestamp":1785773511611,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T00:00:00Z","timestamp":1161216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Primary hyperparathyroidism (PHPT) is characterized by elevated plasma levels of PTH and calcium with reduced plasma phosphate. Physiologically, renal 1\u03b1,25\u2010dihydroxyvitamin\u00a0D [1,25(OH)<jats:sub>2<\/jats:sub>D] production is stimulated by PTH and phosphate deprivation, and inhibited by 1,25(OH)<jats:sub>2<\/jats:sub>D itself and calcium.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate relations between circulating levels of 1,25(OH)<jats:sub>2<\/jats:sub>D, 25\u2010dihydroxyvitamin\u00a0D (25OHD), PTH, calcium, phosphate, renal function and skeletal complications in patients with PHPT.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Cross\u2010sectional study.<\/jats:p><jats:p><jats:bold>Material\u2002<\/jats:bold> Two hundred and fifty\u2010two consecutive hypercalcaemic Caucasian patients aged 24\u201391 (median 65\u00b79)\u00a0years (85\u00b73% females) with PHPT.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In patients with PHPT, plasma 1,25(OH)<jats:sub>2<\/jats:sub>D was increased by 27%[107\u00a0(9\u2013250)\u00a0pmol\/l, median\u00a0(range)] compared to controls [84\u00a0(18\u2013172)\u00a0pmol\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001]. In univariate models, plasma 1,25(OH)<jats:sub>2<\/jats:sub>D depended inversely on age (<jats:italic>r<\/jats:italic>\u00a0=\u00a0<jats:italic>\u2013<\/jats:italic>0\u00b723, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and plasma phosphate (<jats:italic>r<\/jats:italic>\u00a0=\u00a0<jats:italic>\u2013<\/jats:italic>0\u00b723, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and positively on plasma calcium (<jats:italic>r<\/jats:italic>\u00a0= 0\u00b714, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), plasma 25OHD (<jats:italic>r<\/jats:italic>\u00a0= 0,15, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) and creatinine clearance rate (<jats:italic>r<\/jats:italic>\u00a0= 0\u00b732, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). In the final multiple regression model, plasma 1,25(OH)<jats:sub>2<\/jats:sub>D depended positively on renal function (<jats:italic>r<\/jats:italic><jats:sub>p<\/jats:sub>\u00a0=\u00a00\u00b743, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and female sex (<jats:italic>r<\/jats:italic><jats:sub>p<\/jats:sub>\u00a0=\u00a00\u00b715, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) but inversely on body mass index (BMI; <jats:italic>r<\/jats:italic><jats:sub>p<\/jats:sub>\u00a0=\u00a0\u22120\u00b723, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7005) and plasma phosphate (<jats:italic>r<\/jats:italic><jats:sub>p<\/jats:sub>\u00a0=\u00a0\u22120\u00b718, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Plasma 1,25(OH)<jats:sub>2<\/jats:sub>D correlated positively with renal calcium excretion and inversely with lumbar spine bone mineral density (BMD) but was not associated with risk of fractures or renal stones.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Patients with PHPT have elevated plasma 1,25(OH)<jats:sub>2<\/jats:sub>D levels but, to a large extent, individual values overlap controls. The increase in plasma 1,25(OH)<jats:sub>2<\/jats:sub>D depends on renal function, hypophosphataemia and the female sex and is attenuated by high BMI. High plasma 1,25(OH)<jats:sub>2<\/jats:sub>D is associated with higher plasma calcium levels.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02680.x","type":"journal-article","created":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T10:00:19Z","timestamp":1161252019000},"page":"35-42","source":"Crossref","is-referenced-by-count":27,"title":["Plasma 1,25\u2010dihydroxyvitamin\u00a0D levels in primary hyperparathyroidism depend on sex, body mass index, plasma phosphate and renal 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