{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:30:34Z","timestamp":1793154634364,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,20]],"date-time":"2006-11-20T00:00:00Z","timestamp":1163980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    \u2002Bilateral inferior petrosal sinus sampling (BIPSS) with corticotrophin\u2010releasing hormone (CRH) stimulation is currently the gold standard test for the differential diagnosis of ACTH\u2010dependent Cushing's syndrome. Reports on the use of desmopressin in this approach are limited. The aim of this study was to evaluate the use of desmopressin during BIPSS in a cohort of patients with ACTH\u2010dependent Cushing's syndrome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design\u2002<\/jats:bold>\n                    \u2002A retrospective case\u2010record study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients\u2002\u2002<\/jats:bold>\n                    Fifty\u2010six patients with confirmed ACTH\u2010dependent Cushing's syndrome underwent BIPSS with desmopressin stimulation when presenting negative pituitary tumour imaging.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Measurements\u2002\u2002<\/jats:bold>\n                    Central to peripheral (CEN:PER) ACTH gradient, lateralization of the ACTH source and surgical tumour confirmation were evaluated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002\u2002<\/jats:bold>\n                    A CEN:PER ACTH gradient was found in 40 patients under basal conditions (CEN:PER\u00a0\u2265\u00a02) and in 47 patients after desmopressin stimulation (CEN:PER\u00a0\u2265\u00a03). Ectopic ACTH\u2010producing tumours (three lung carcinoid tumour, one thymus carcinoid tumour and one thymus hyperplasia) were confirmed in five out of nine patients without the CEN:PER ACTH gradient, and four cases were false negative for Cushing's disease. Lateralization (IPS:IPS\u00a0\u2265\u00a01\u00b74) was observed in 80\u00b78% of patients under basal conditions (38\/47) and in 97\u00b78% after desmopressin (46\/47), and it was surgically confirmed in 78\u00b77%. There were no false\u2010positive cases. Sensitivity and specificity were 92\u00b71% and 100%, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    \u2002Desmopressin improves the differential diagnosis of ACTH\u2010dependent Cushing's syndrome by amplifying the CEN:PER and IPS:IPS ACTH gradients, and is therefore a useful ACTH secretagogue in BIPSS.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2265.2006.02700.x","type":"journal-article","created":{"date-parts":[[2006,11,20]],"date-time":"2006-11-20T04:25:26Z","timestamp":1163996726000},"page":"136-142","source":"Crossref","is-referenced-by-count":81,"title":["The role of desmopressin in bilateral and simultaneous inferior petrosal sinus sampling for differential diagnosis of ACTH\u2010dependent Cushing's syndrome"],"prefix":"10.1111","volume":"66","author":[{"given":"Marcio Carlos","family":"Machado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Valeria","family":"De Sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorahia","family":"Domenice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Candida B. Villares","family":"Fragoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Paulo","family":"Puglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Adelaide Albergaria","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice Bilharinho","family":"De Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Roberto","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019616-199707030-00001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00702.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109263251301"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197704142961508"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-5-647"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-5-1070"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.150.1.6316418"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1986.tb03624.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.5.647"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.2.440"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.2.487"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1440499"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020374"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2005.01.009"},{"key":"e_1_2_6_16_2","first-page":"690","article-title":"Adrenocorticotropic hormone\u2010dependent Cushing's syndrome: sensitivity and specificity of inferior petrosal sinus sampling","volume":"21","author":"Bonelli F.S.","year":"2000","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1525"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2527"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.6.1087"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.305"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb00341.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.5.1768"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00850.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.176.2.2164235"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.2.475"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2006.02700.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2006.02700.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T03:36:21Z","timestamp":1697168181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2006.02700.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,20]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2265.2006.02700.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02700.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,20]]}}}