{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:56:28Z","timestamp":1790988988696,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:00:00Z","timestamp":1172620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Andriol\u00ae Testocaps\u00ae is a new oral formulation of testosterone undecanoate (TU) for treatment of hypogonadism. As TU is taken up by the intestinal lymphatic system, both the presence and the composition of food influence the absorption. The aim of this study was to investigate the effect of food composition on the pharmacokinetics of oral TU.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> An open\u2010label, single\u2010centre, four\u2010way crossover study. With a washout period of 6\u20137\u00a0days, 80\u00a0mg TU was administered in the morning 5\u00a0min after consuming each of four different meals in a randomized order (A: 230\u00a0kcal, 0\u00b76\u00a0g lipid; B: 220\u00a0kcal, 5\u00a0g lipid; C: 474\u00a0kcal, 19\u00a0g lipid; D: 837\u00a0kcal, 44\u00a0g lipid).<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Twenty\u2010four postmenopausal volunteers.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Serial blood samples were collected until 24\u00a0h after dosing to determine testosterone and dihydrotestosterone (DHT) by gas chromatography\u2010mass spectroscopy (GC\u2010MS).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The bioavailability of testosterone after a low\u2010calorie meal containing 0\u00b76\u00a0g lipid or 5\u00a0g lipid was relatively low, the area under the concentration\u2013time curve (AUC<jats:sub>0\u2013tlast<\/jats:sub>) for testosterone being 30\u00b77 and 43\u00b75\u00a0nmol\u00a0h\/l, respectively. The bioavailability of testosterone after a meal containing 19\u00a0g lipid was considerably higher (AUC<jats:sub>0\u2013tlast<\/jats:sub>\u00a0= 146\u00a0nmol\u00a0h\/l), whereas increasing the lipid content to 44\u00a0g lipid did not further increase the bioavailability of testosterone (AUC<jats:sub>0\u2013tlast<\/jats:sub>\u00a0=\u00a0154\u00a0nmol\u00a0h\/l).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Approximately 19\u00a0g of lipid per meal efficiently increases absorption of testosterone from oral TU. Therefore, coadministration with a normal rather than a fatty meal is sufficient to increase serum testosterone levels when using oral TU.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.02781.x","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T12:37:25Z","timestamp":1172666245000},"page":"579-585","source":"Crossref","is-referenced-by-count":47,"title":["The effect of food composition on serum testosterone levels after oral administration of Andriol<sup>\u00ae<\/sup> Testocaps<sup>\u00ae<\/sup>"],"prefix":"10.1111","volume":"66","author":[{"given":"Peter G.","family":"Schnabel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Bagchus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Lass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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