{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:32:06Z","timestamp":1761561126483},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T00:00:00Z","timestamp":1171324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acromegaly is associated with hypertrophic cardiomyopathy, hypertension and subsequent congestive heart failure. Impairment of cardiac function has also been associated with growth hormone deficiency (GHD). B\u2010type natriuretic peptides (BNPs) have emerged as strong diagnostic and prognostic risk markers. They are cardioprotective hormones that compensate heart disease by promoting natriuresis and modulation of cardiac hypertrophy in response to volume expansion and ventricular wall stretch.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate N\u2010terminal pro\u2010BNP (NT\u2010proBNP) in patients with GH disturbances before and after treatment, and in healthy gender\u2010 and age\u2010matched controls.<\/jats:p><jats:p><jats:bold>Subjects and methods\u2002<\/jats:bold> Ten acromegalic patients (age 48\u00a0\u00b1\u00a012 years) and 10 patients with GHD (age 41\u00a0\u00b1\u00a014\u00a0years) were studied. None had symptoms or signs of cardiovascular disease except for hypertension. Serum NT\u2010proBNP was measured before and 3, 6, 12 and 24\u00a0months after treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Baseline NT\u2010proBNP was lower in acromegalic patients [median (interquartile range) 24\u00b73\u00a0(17\u00b78\u201333\u00b70)\u00a0pg\/ml] than in 20 healthy matched controls [57\u00b79\u00a0(35\u00b74\u201392\u00b72)\u00a0pg\/ml; <jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001]. NT\u2010proBNP increased during treatment (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7002), concomitant with a decrease in IGF\u2010I (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001). After 3\u00a0months of treatment NT\u2010proBNP peaked, with a fourfold increase to 96\u00b74\u00a0(57\u00b78\u2013113\u00b72)\u00a0pg\/ml. NT\u2010proBNP did not differ in patients with GHD compared with controls (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b719), and did not change during treatment (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b739).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Untreated patients with acromegaly had low NT\u2010proBNP levels that increased fourfold after treatment. This is in contrast to other conditions with cardiac hypertrophy. Further studies are required to determine the significance of this novel finding in relation to acromegalic cardiac disease.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.02782.x","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T13:39:29Z","timestamp":1171373969000},"page":"619-625","source":"Crossref","is-referenced-by-count":11,"title":["N\u2010terminal pro\u2010B\u2010type natriuretic peptide in patients with growth hormone disturbances"],"prefix":"10.1111","volume":"66","author":[{"given":"Mikkel","family":"Andreassen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Faber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Kistorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars \u00d8stergaard","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000030720.29247.9F"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01218.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-6374(03)00011-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0009"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb03789.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.4.1047"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.10.3419"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1381"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91812-O"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1169"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"e_1_2_6_13_2","first-page":"1","article-title":"Growth hormone and the cardiovascular function","volume":"30","author":"Svensson J.","year":"2005","journal-title":"Minerva Endocrinology"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031601"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00267-8"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0597"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.2.659"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000100720.01867.1D"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063212"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.10.054"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2004.07.002"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.12.010"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi406"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.07.019"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.10.001"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.153"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.05.001"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1609"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi204"},{"key":"e_1_2_6_30_2","first-page":"197","article-title":"The pyridostigmine\u2013growth\u2010hormone\u2010releasing\u2010hormone in adults. 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