{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T05:23:42Z","timestamp":1746336222657},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T00:00:00Z","timestamp":1171324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate whether markers in the candidate chromosome regions, including the human leucocyte antigen (HLA) region, are linked to Graves\u2019 disease (GD).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A familial linkage study with a candidate region approach.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> A total of 536 individuals in 122 multiplex Chinese\u2010Han families with a GD proband and at least one other affected sibling, resulting in 270 affected sib\u2010pairs. Subjects with a family history of noniatrogenic hypothyroidism or Hashimoto's thyroiditis were excluded.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> We genotyped eight short tandem repeat polymorphism (STRP) markers in a 13\u00b77\u00a0cM region covering the HLA region on chromosome\u00a06p21 and 26 STRPs in four other candidate regions previously reported in the literature.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Multipoint nonparametric linkage (NPL) analysis showed significant linkage to the HLA region [the marker UniSTS:239159, nonparametric log of odds (LOD) score 3\u00b744, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b700003; NPL <jats:italic>Z<\/jats:italic>\u2010score 4\u00b71, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b700002] from 270 affected sib\u2010pairs. The 1\u2010LOD support interval comprised the whole HLA region (<jats:italic>ca<\/jats:italic>.\u00a04\u00a0Mb). By contrast, the maximal NPL Z\u2010scores of the markers of the other candidate regions (2q33, 5q31, 7q22 and 14q31) previously reported were all less than 1\u00b70.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our results provide strong support for linkage of GD to the HLA region. Further dissection of this region to identify the candidate gene for GD is warranted in our population.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.02787.x","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T13:39:29Z","timestamp":1171373969000},"page":"646-651","source":"Crossref","is-referenced-by-count":8,"title":["Linkage of Graves\u2019 disease to the human leucocyte antigen region in the Chinese\u2010Han population in Taiwan"],"prefix":"10.1111","volume":"66","author":[{"given":"Pei\u2010Lung","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy 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