{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:41:29Z","timestamp":1793277689952,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T00:00:00Z","timestamp":1174608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Pain is one of the few drawbacks of fine\u2010needle aspiration biopsy (FNAB) in patients with nodular thyroid disease (NTD). Lidocaine\/prilocaine cream, an eutectic mixture of local anaesthetics (EMLA), is a frequently used topical anaesthetic. Despite its well\u2010documented efficacy for the relief of pain associated with other cutaneous procedures that involve needle insertion, the analgesic role of EMLA has not been previously reported in patients with NTD who are undergoing FNAB. The aim of this study was to determine the analgesic efficacy of EMLA for FNAB\u2010associated pain in patients with NTD.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Double\u2010blind, placebo\u2010controlled clinical trial.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> The study was conducted at a thyroid outpatient clinic. We studied 99 patients with NTD.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Patients with NTD were allocated to receive either 2\u00b75\u00a0g of EMLA (<jats:italic>n<\/jats:italic>\u00a0=\u00a050) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a049) 60\u00a0min before ultrasonographically guided FNAB. A series of four biopsies of each nodule was performed. Patients rated pain associated with the procedure according to a 100\u2010mm visual analogue scale (VAS), an 11\u2010point numeric rating scale (NRS), and 4\u2010category verbal rating scale (VRS).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> When the EMLA group was compared with the placebo group, there were no significant differences with respect to age, sex, thyroid volume, nodule size or nodule site. Significant differences were noted in the pain ratings of the two groups according to all three pain scales. When the effectiveness of EMLA was compared with that of placebo, the mean VAS score was 25\u00b70\u00a0\u00b1\u00a022\u00b73\u00a0mm <jats:italic>vs.<\/jats:italic> 40\u00b70\u00a0\u00b1\u00a030\u00b75\u00a0mm (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7006) and the mean NRS score was 2\u00b79\u00a0\u00b1\u00a02\u00b73 points <jats:italic>vs.<\/jats:italic> 4\u00b70\u00a0\u00b1\u00a02\u00b76 points (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b702). The absolute numbers according to VRS score in each group was also significantly different (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b701). Although our sample size was small, the data suggest that FNAB\u2010associated pain was sex\u2010related and that women were significantly more sensitive than were men (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7003 for VAS score and <jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7001 for NRS score). No adverse effects from the use of EMLA were reported.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> To our knowledge, this is the first study demonstrating that a topical anaesthetic, EMLA, provides an effective and noninvasive analgesia during the FNAB of NTD.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.02802.x","type":"journal-article","created":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T09:03:53Z","timestamp":1174640633000},"page":"691-694","source":"Crossref","is-referenced-by-count":34,"title":["The analgesic efficacy of lidocaine\/prilocaine (EMLA) cream during fine\u2010needle aspiration biopsy of thyroid nodules"],"prefix":"10.1111","volume":"66","author":[{"given":"Alptekin","family":"Gursoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derun Taner","family":"Ertugrul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan Bascil","family":"Tutuncu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli Nar","family":"Demirer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilgun Guvener","family":"Demirag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.12.1.63"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199512000-00003"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03013153"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05830.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2005.01.028"},{"key":"e_1_2_5_7_2","first-page":"561","article-title":"EMLA cream effectively reduces the pain of spinal needle insertion","volume":"21","author":"Sharma S.K.","year":"1996","journal-title":"Regional Anesthesia"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00178-H"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-5900(03)00716-8"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200003000-00005"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00427-4"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000080153.36643.83"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90094-E"},{"key":"e_1_2_5_14_2","first-page":"72","article-title":"Randomized prospective study of local transdermic anesthetic in fine needle aspiration biopsy for breast lumps","volume":"83","author":"De Freitas R.","year":"1998","journal-title":"International Surgery"},{"key":"e_1_2_5_15_2","first-page":"458","article-title":"Fine\u2010needle aspiration biopsy: is anesthesia necessary?","volume":"120","author":"Cannon C.R.","year":"1999","journal-title":"Otolaryngology Head and Neck Surgery"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2007.02802.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2007.02802.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T07:59:18Z","timestamp":1697183958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2007.02802.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,23]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1111\/j.1365-2265.2007.02802.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2007.02802.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,23]]}}}