{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:36:59Z","timestamp":1791286619633,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T00:00:00Z","timestamp":1175644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Serum androgen levels are below normal in patients with benign cortisol\u2010secreting adrenocortical adenomas, owing to ACTH suppression. Associated androgen secretion is usually considered as indicative of malignancy. The objective of the study was to analyse the androgen\u2010producing ability of cortisol\u2010secreting adrenocortical adenomas.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Retrospective data collection in a single referral hospital centre.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Dehydroepiandrosterone sulfate (DHEAS), \u03944androstenedione and testosterone concentrations were measured before and after adrenalectomy and then at 6\u2010month intervals in 20 women (eight cortisol\u2010secreting adrenocortical adenomas, six subclinical cortisol\u2010secreting adrenocortical adenomas, and six nonfunctional adenomas).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Before adrenalectomy, serum androgen concentrations were measurable in all women with clinically apparent and subclinical cortisol\u2010secreting adrenocortical adenomas. DHEAS levels were either at the lower end of the normal range or below normal, but were always clearly detectable. Postoperatively, during adrenocortical insufficiency, DHEAS, \u03944androstenedione and testosterone concentrations fell to near the detection limit in all patients with cortisol\u2010secreting adrenocortical adenomas (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7008 for each marker) and showed a similar tendency to fall in all patients with subclinical cortisol\u2010secreting adrenocortical adenomas. Pre\u2010 and post\u2010treatment androgen concentrations did not differ in patients with nonfunctional adenomas. Immunohistochemical analysis confirmed CYP17, HSD3B2, SULT2A1 and CYB5 expression by all cortisol\u2010producing tumours. The intensity of CYP17 and SULT2A1 expression was stronger in cortisol\u2010secreting adenomas than in their adjacent normal adrenal tissue.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Both clinically apparent and subclinical cortisol\u2010secreting adrenocortical adenomas appear to show moderate autonomous androgen production. Thus, weak androgen secretion in patients with adrenocortical tumours should not necessarily be considered as a sign of malignancy.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.02810.x","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T19:34:34Z","timestamp":1175715274000},"page":"778-788","source":"Crossref","is-referenced-by-count":21,"title":["Benign cortisol\u2010secreting adrenocortical adenomas produce small amounts of androgens"],"prefix":"10.1111","volume":"66","author":[{"given":"Peter","family":"Kamenicky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Houdoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Ferlicot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Salenave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Brailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Droupy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geri","family":"Meduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-29-2-273"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-6-1164"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.32.691"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.43.387"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-29-11-1443"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2005.01.002"},{"key":"e_1_2_5_8_2","first-page":"891","article-title":"Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland","volume":"8","author":"Sasano H.","year":"1995","journal-title":"Modern Pathology"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.6.1532"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1420611"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0031"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-5347(17)41471-6","article-title":"Steroid content of the peripheral and adrenal vein in Cushing's syndrome due to adrenocortical adenoma and carcinoma","volume":"140","author":"Levine A.C.","year":"1988","journal-title":"The Journal of Urology"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503233321207"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00357.x"},{"key":"e_1_2_5_15_2","first-page":"637","article-title":"A survey on adrenal incidentaloma in Italy. 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