{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:56:34Z","timestamp":1773273394644,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T00:00:00Z","timestamp":1175644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold>The Asp727Glu polymorphism in the TSH receptor (TSHR) gene is associated with serum TSH levels. However, the proportion of genetic variation accounted for by this polymorphism is unknown. In this study, we (1) examined the association of the Asp727Glu polymorphism with thyroid size, serum levels of TSH, thyroid hormones, and thyroid antibodies in 1241 healthy Danish twin individuals and (2) assessed the contribution of the polymorphism to the trait variation and the genetic variance.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold>The effect of the genotype on the traits (mean\u00a0\u00b1\u00a0SD) was established; associations between the TSHR\u2010Asp727Glu polymorphism and measures of thyroid homeostasis were assessed and the effect of the polymorphism on the trait's phenotypic variability was quantified by incorporating the genotype information in structural equation modelling.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>The genotype distribution was Asp\/Asp 84\u00b79%; Asp\/Glu 14\u00b75% and Glu\/Glu 0\u00b76%. Carriers of the TSHR\u2010Glu727 allele had lower TSH levels (noncarriers<jats:italic>vs.<\/jats:italic>carriers: 1\u00b778\u00a0\u00b1\u00a00\u00b793<jats:italic>vs.<\/jats:italic>1\u00b760\u00a0\u00b1\u00a00\u00b784\u00a0mU\/l,<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704). Regression analysis showed an association between the TSHR\u2010Asp727Glu polymorphism and serum TSH (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7007). The polymorphism accounted for 0\u00b791% of the total phenotypic variance in serum TSH levels. Including the genotype in quantitative genetic modelling improved the model fit (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7001); however, the genetic influence on serum TSH not attributable to this specific genetic variant was only reduced from 68\u00b72% to 67\u00b78%. The polymorphism was not significantly associated with thyroid size, thyroid hormones or thyroid antibody levels.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>The TSHR\u2010727Glu allele was associated with decreasing TSH levels; however, the contribution to the genetic variance was very small. No association was found with other thyroid\u2010related measures.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.02820.x","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T19:34:34Z","timestamp":1175715274000},"page":"827-832","source":"Crossref","is-referenced-by-count":43,"title":["The impact of a TSH receptor gene polymorphism on thyroid\u2010related phenotypes in a healthy Danish twin population"],"prefix":"10.1111","volume":"66","author":[{"given":"Pia Skov","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy M.","family":"Van Der Deure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin P.","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Iachine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens","family":"Fenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorkild I. 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