{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T02:53:18Z","timestamp":1716000798303},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T00:00:00Z","timestamp":1176336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2003<\/jats:bold> The cellular effects of growth hormone (GH) are mediated by the interaction between GH and the GH receptor (GHR). We investigated the association between polymorphisms in <jats:italic>GHR<\/jats:italic> and changes in height standard deviation scores (SDS), and lipid metabolism during GH treatment for GH\u2010deficient children.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> A 1\u2010year study on growth rate and lipid metabolism under GH treatment.<\/jats:p><jats:p><jats:bold>Patients\u2003<\/jats:bold> Eighty\u2010three children (61 boys and 22 girls) with GH deficiency were treated with GH for 1\u00a0year after diagnosis.<\/jats:p><jats:p><jats:bold>Intervention\u2003<\/jats:bold> The patients were treated with recombinant human GH (0\u00b719\u00a0mg\/kg\/week) for at least 1\u00a0year after diagnosis. The growth rates and biochemical parameters for lipid metabolism were measured both before and during treatment. Four single nucleotide polymorphisms (SNPs) in the <jats:italic>GHR<\/jats:italic> gene, Cys440Phe, Pro495Thr, Leu544Ile and Pro579Thr, and exon 3 deletion polymorphisms were genotyped by direct sequencing and multiplex PCR.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> We found no significant association between <jats:italic>GHR<\/jats:italic> polymorphisms and changes in height SDS during GH treatment. The total cholesterol levels of the GH\u2010deficient boys with Ile\/Ile at codon 544 showed significantly higher cholesterol levels before GH treatment and then maintained high levels during the GH treatment, compared to those with other genotypes. No other polymorphisms seemed to have any apparent effects on lipid metabolism.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> The Leu544Ile polymorphism of the <jats:italic>GHR<\/jats:italic> gene is associated with cholesterol levels in boys with GH deficiency.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.02863.x","type":"journal-article","created":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T09:56:14Z","timestamp":1180950974000},"page":"212-217","source":"Crossref","is-referenced-by-count":9,"title":["The Leu544Ile polymorphism of the growth hormone receptor gene affects the serum cholesterol levels during GH treatment in children with GH deficiency"],"prefix":"10.1111","volume":"67","author":[{"given":"K.","family":"Ihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Inuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kuromaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Miyako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kinukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2003.10.001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.11.3990"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1210\/jcem.82.2.3734","article-title":"Adult height in growth hormone (GH)\u2010deficient children treated with biosynthetic GH. 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