{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T17:51:36Z","timestamp":1721584296474},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T00:00:00Z","timestamp":1180483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Turner syndrome (TS) is an indication for GH therapy in spite of the modest growth response. Somatic growth depends not only on GH insulin\u2010like growth factor I (IGF\u2010I) axis but also on thyroid hormone (TH) status. We have previously reported that supraphysiological IGF\u2010I levels diminished TH actions in rat tissues by reducing the nuclear TH receptor (TR). GH treatment to TS patients induces high IGF\u2010I levels and therefore a reduction of TH action in tissues may be expected. We aimed at evaluating the effect of GH therapy in TS girls on peripheral TH action.<\/jats:p><jats:p><jats:bold>Design and patients\u2002<\/jats:bold> We set up a reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) for TR mRNA estimation in peripheral blood mononuclear cells (PBMC) and compared TR mRNA levels from 10 normal, 10 TS and 10 TS girls under GH therapy (0\u00b733\u00a0mg\/kg\/week for 0\u00b75\u20132\u00a0years).<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> After RNA extraction from PBMC, TR and \u03b2\u2010actin mRNAs were coamplified by RT\u2010PCR. In addition serum biochemical markers of TH action were measured: thyrotropin (TSH), sex hormone binding globulin (SHBG), osteocalcin (OC), \u03b2\u2010crosslaps (\u03b2\u2010CL), iodothyronines by electrochemiluminescency and IGF\u2010I by immunoradiometric assay (IRMA) with extraction.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> TR mRNAs from PBMC were reduced in TS patients under GH treatment. In turn, serum TSH, OC, \u03b2\u2010CL and IGF\u2010I were increased while SHBG was reduced by GH treatment in TS patients.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> GH treatment reduced TR expression in PBMC and biochemical serum markers of TH action. These results suggest that GH treatment in TS patients impair peripheral TH action at tissue level and prompt a role in the reduced growth response to the therapy.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.02936.x","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T02:44:27Z","timestamp":1185849867000},"page":"629-636","source":"Crossref","is-referenced-by-count":8,"title":["Growth hormone (GH) treatment reduces peripheral thyroid hormone action in girls with Turner syndrome"],"prefix":"10.1111","volume":"67","author":[{"given":"S.","family":"Susperreguy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Miras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Montesinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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