{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:27:14Z","timestamp":1765826834323},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,7,26]],"date-time":"2007-07-26T00:00:00Z","timestamp":1185408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2003<\/jats:bold> To examine quality of life (QoL) measured by a utility\u2010weighted index in GH\u2010deficient adults on GH replacement and analyse the impact of demographic and clinical characteristics on changes in utilities during treatment.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> Utilities for items in the QoL\u2010Assessment of Growth Hormone Deficiency in Adults (QoL\u2010AGHDA<jats:sub>utility<\/jats:sub>) were estimated based on data obtained from the general population in England and Wales (E&amp;W). These estimates were used to calculate QoL changes in GH\u2010treated patients and compare these with normative population values.<\/jats:p><jats:p><jats:bold>Patients\u2003<\/jats:bold> A total of 894 KIMS patients (53% women) from E&amp;W were followed for 1 to 6\u00a0years.<\/jats:p><jats:p><jats:bold>Measurements\u2003<\/jats:bold> QoL\u2010AGHDA<jats:sub>utility<\/jats:sub> at baseline and at the last reported visit, total QoL\u2010AGHDA<jats:sub>utility<\/jats:sub> gain and QoL\u2010AGHDA<jats:sub>utility<\/jats:sub> gain per year of follow\u2010up.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> QoL\u2010AGHDA<jats:sub>utility<\/jats:sub> in patients before GH treatment differed from the expected population values [0\u00b767\u00a0(SD\u00a00\u00b7174) <jats:italic>vs.<\/jats:italic> 0\u00b785 (SD\u00a00\u00b7038), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001], constituting a mean deficit of \u20130\u00b719\u00a0(SD\u00a00\u00b7168). There was a difference in the mean QoL\u2010AGHDA<jats:sub>utility<\/jats:sub> deficit for men [\u20130\u00b716\u00a0(SD\u00a00\u00b7170)] and women [\u20130\u00b721\u00a0(SD\u00a00\u00b7162)] (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001). The main improvement occurred during the first year of treatment [reduction of a deficit to \u20130\u00b707\u00a0(SD\u00a00\u00b7163) (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001) in the total cohort]; however, patients\u2019 utilities remained lower than those recorded for the general population during subsequent follow\u2010up (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001). Despite an observed impact of age, primary aetiology, disease onset and comorbidities on QoL\u2010AGHDA<jats:sub>utility<\/jats:sub>, all patients showed a similar beneficial response to treatment.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> QoL\u2010AGHDA<jats:sub>utility<\/jats:sub> efficiently monitors treatment effects in patients with GHD. The study confirmed the QoL\u2010AGHDA<jats:sub>utility<\/jats:sub> deficit before treatment and a similar QoL\u2010AGHDA<jats:sub>utility<\/jats:sub> gain observed after commencement of GH replacement in all patients.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03010.x","type":"journal-article","created":{"date-parts":[[2007,9,7]],"date-time":"2007-09-07T20:22:56Z","timestamp":1189196576000},"page":"122-129","source":"Crossref","is-referenced-by-count":18,"title":["Growth hormone (GH) replacement in hypopituitary adults with GH deficiency evaluated by a utility\u2010weighted quality of life index: a precursor to cost\u2013utility analysis"],"prefix":"10.1111","volume":"68","author":[{"given":"Maria","family":"Ko\u0142towska\u2010H\u00e4ggstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Monson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-6296(86)90020-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/0470846283","volume-title":"Quality of Life, Assessment, Analysis and Interpretation","author":"Fayers P.M.","year":"2000"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1210\/jcem.83.2.4594","article-title":"Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee","volume":"83","author":"Carroll P.V.","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200422080-00003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008987922774"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450255"},{"key":"e_1_2_6_8_2","first-page":"1","article-title":"Estimating the health utility of treatment in adults with growth hormone deficiency","volume":"7","author":"Dixon S.","year":"2003","journal-title":"Journal of Outcomes Research"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2006.00146.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2004.08.034"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:QURE.0000037498.00754.b8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00171.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199711000-00002"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087444"},{"key":"e_1_2_6_16_2","first-page":"10","article-title":"KIMS: treating adult GH deficiency","volume":"68","author":"Monson J.P.","year":"2003","journal-title":"Endocrinologist"},{"key":"e_1_2_6_17_2","first-page":"170","volume-title":"Assessment of Quality of Life in Clinical Trials of Cardiovascular Therapies","author":"Dupuy H.J.","year":"1984"},{"key":"e_1_2_6_18_2","first-page":"346","volume-title":"Growth Hormone Deficiency in Adults: 10\u00a0Years of KIMS","author":"KIMS Classification List","year":"2004"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(97)00057-9"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X04268955"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X9901900416"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-0233-1_9"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta6180"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02176"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02149"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030134"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.3271123.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199806000-00002"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8510(00)00111-1"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071235"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000012276"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1169"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91812-O"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2007.03010.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2007.03010.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:25:53Z","timestamp":1697232353000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2007.03010.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,26]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1111\/j.1365-2265.2007.03010.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2007.03010.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,26]]}}}