{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:00:36Z","timestamp":1788447636246,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T00:00:00Z","timestamp":1185753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2003<\/jats:bold>\n                    Several studies have reported a high prevalence of hypopituitarism after traumatic brain injury (TBI). Risk stratification is a prerequisite for cost\u2010effective hormonal screening of these patients. However, it is still unclear which risk factors predispose patients to develop anterior hypopituitarism after TBI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2003<\/jats:bold>\n                    To assess clinical and radiological risk factors for post\u2010traumatic hypopituitarism.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods\u2003<\/jats:bold>\n                    Seventy\u2010eight consecutive patients (52 men, 26 women; mean age 36\u00b70\u00a0years, range 18\u201365\u00a0years) with mild, moderate or severe TBI were studied. Endocrine and clinical parameters were assessed 3 and 12\u00a0months after TBI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2003<\/jats:bold>\n                    We found diffuse axonal injury, basal skull fracture and older age to be major risk factors of post\u2010traumatic hypopituitarism.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2003<\/jats:bold>\n                    We have defined specific risk factors for the development of post\u2010traumatic hypopituitarism that are consistent with pathophysiological considerations. These findings might help to identify at\u2010risk patients.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03020.x","type":"journal-article","created":{"date-parts":[[2007,9,7]],"date-time":"2007-09-07T16:22:56Z","timestamp":1189182176000},"page":"206-212","source":"Crossref","is-referenced-by-count":92,"title":["Predictors of anterior pituitary insufficiency after traumatic brain injury"],"prefix":"10.1111","volume":"68","author":[{"given":"M.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Yassouridis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Saller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Von Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. K.","family":"Stalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1261","article-title":"Pituitary damage due to basal skull fracture (in German)","volume":"44","author":"Cyran E.","year":"1918","journal-title":"Deutsche Medizinische Wochenschrift"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.4.6506"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2005.22.937"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02517.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.5.0743"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.6.2752"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02094.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/0897715041269713"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0511"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0504"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02071"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/02699050400025315"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-005-0724-y"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0140-6736(74)91639-0","article-title":"Assessment of coma and impaired consciousness: a practical scale","volume":"13","author":"Teasdale G.","year":"1974","journal-title":"Lancet"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540473"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071871"},{"key":"e_1_2_6_18_2","first-page":"309","article-title":"CT for acute stage of closed head injury","volume":"23","author":"Toyama Y.","year":"2005","journal-title":"Radiation Medicine"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.25137"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1989.tb03040.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00117-003-0962-z"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/94.1.165"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(59)91583-1"},{"key":"e_1_2_6_25_2","first-page":"242","article-title":"Pituitary lesions in craniocerebral injuries","volume":"88","author":"Kornblum R.N.","year":"1969","journal-title":"Archives of Pathology"},{"key":"e_1_2_6_26_2","first-page":"185","article-title":"Pituitary changes in head trauma (analysis of 102 consecutive cases of head injury)","volume":"3","author":"Ceballos R.","year":"1966","journal-title":"Alabama Journal of Medical Science"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.90.6.1141"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.7.3217"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2002.00534.x"},{"issue":"1","key":"e_1_2_6_30_2","first-page":"18","article-title":"Head injury for neurologists","volume":"73","author":"Greenwood R.","year":"2002","journal-title":"Journal of Neurological Neurosurgery and Psychiatry"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000196002.03681.18"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2004.06.012"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8201"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2007.03020.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2007.03020.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:23:10Z","timestamp":1697214190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2007.03020.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,30]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1365-2265.2007.03020.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2007.03020.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,30]]}}}