{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:44:44Z","timestamp":1761155084248},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T00:00:00Z","timestamp":1187568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate whether absence of secondary hyperparathyroidism in the presence of hypovitaminosis\u00a0D has altered bone turnover, fracture risk and mortality.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A prospective cohort study.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> A total of 1280 older men and women living in residential care facilities.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> We measured baseline serum 25\u2010hydroxyvitamin D (25OHD), serum intact PTH, serum amino\u2010terminal propeptide of type\u00a0I collagen (PINP) and serum carboxy\u2010terminal telopeptide of type\u00a0I collagen (CTX\u2010I). Deaths and fractures were recorded prospectively.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Hypovitaminosis\u00a0D (25OHD\u00a0&lt;\u00a039\u00a0nmol\/l) and absence of secondary hyperparathyroidism (PTH\u00a0&gt;\u00a07\u00b70\u00a0pmol\/l) in the presence of hypovitaminosis\u00a0D were common in this sample with a prevalence of 77\u00b75% and 53\u00b73%, respectively. In the presence of hypovitaminosis\u00a0D, residents showing a hyperparathyroid response (<jats:italic>n<\/jats:italic>\u00a0=\u00a0406) had significantly higher serum bone turnover markers than individuals with serum PTH levels\u00a0\u2264\u00a07\u00b70\u00a0pmol\/l (termed \u2018low vitamin\u00a0D, normal PTH\u2019, <jats:italic>n<\/jats:italic>\u00a0=\u00a0463). After adjusting for risk factors, mortality was significantly higher in the secondary hyperparathyroidism group than in the \u2018low vitamin\u00a0D, normal PTH\u2019 group [hazard ratio (HR)\u00a0=\u00a01\u00b735, 95% confidence interval (CI) 1\u00b712\u20131\u00b764; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002]. All residents with serum PTH levels\u00a0\u2264\u00a07\u00b70\u00a0pmol\/l (<jats:italic>n<\/jats:italic>\u00a0=\u00a0603) were similar with regard to both bone turnover and mortality, independent of their actual vitamin\u00a0D status.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Absence of secondary hyperparathyroidism in the presence of hypovitaminosis\u00a0D appears to be common in the frail elderly and is associated with longer survival, similar to that observed in vitamin\u00a0D\u2010replete elderly subjects.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03040.x","type":"journal-article","created":{"date-parts":[[2007,9,16]],"date-time":"2007-09-16T09:23:32Z","timestamp":1189934612000},"page":"290-298","source":"Crossref","is-referenced-by-count":51,"title":["Hypovitaminosis\u00a0D and parathyroid hormone response in the elderly: effects on bone turnover and mortality"],"prefix":"10.1111","volume":"68","author":[{"given":"Jian 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